{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:52:43Z","timestamp":1774241563468,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL 121510"],"award-info":[{"award-number":["R01-HL 121510"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R33-HL-146390"],"award-info":[{"award-number":["R33-HL-146390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL153646"],"award-info":[{"award-number":["R01HL153646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-AG058969"],"award-info":[{"award-number":["R01-AG058969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01-HL104106"],"award-info":[{"award-number":["1R01-HL104106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01-HL094307"],"award-info":[{"award-number":["P01-HL094307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R03-HL146874"],"award-info":[{"award-number":["R03-HL146874"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R56-HL136730"],"award-info":[{"award-number":["R56-HL136730"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Abbott"},{"name":"Boston Scientific"},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Highlife"},{"name":"WL Gore"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Systemic arterial properties contribute to clinical heterogeneity and outcomes in degenerative calcific aortic stenosis (AS). Lumped parameters of afterload have previously been associated with adverse left ventricular remodeling, mortality, and poor exercise tolerance in this population, but most studies did not assess pulsatile aortic pressure\u2013flow relations, the gold standard method for assessing arterial load. Moreover, arterial compliance is highly dependent on nonpulsatile (mean) arterial pressure, which influences prognosis in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We retrospectively studied 135 patients with severe AS with same-day catheterization and echocardiogram. Invasive aortic pressures and echocardiographic flow waveforms were used to assess pressure\u2013flow and pressure\u2013volume relations using Windkessel modeling and wave separation analyses. We used Cox regression to assess the relationship between pulsatile load and time to death and heart failure hospital admission (DHFA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Total arterial compliance accounting for pressure dependence was independently predictive of all-cause mortality (Hazard Ratio (HR)\u2005=\u20050.80, 95% confidence interval [CI]\u2005=\u20050.66\u20130.97; P\u2005=\u20050.023) and DHFA (HR\u2005=\u20050.70; 95% CI\u2005=\u20050.50\u20130.97; P\u2005=\u20050.031) even after adjustment for age, race, gender, body mass index, and comorbidities, whereas other arterial parameters were not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In patients with severe AS, pressure-dependent arterial compliance predicts adverse outcomes, whereas traditional pulsatile arterial load measures do not. Our findings suggest that methods accounting for pressure load on the arterial wall are advantageous in this population in which lower mean pressure can result from severe stenosis and ventricular dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpae127","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T15:18:21Z","timestamp":1727882301000},"page":"321-330","source":"Crossref","is-referenced-by-count":1,"title":["Arterial Properties and Ventricular\u2013Arterial Interactions in Severe Aortic Stenosis: Impact on Prognosis"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-7228","authenticated-orcid":false,"given":"Edward R","family":"Horton","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce V","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-8757","authenticated-orcid":false,"given":"Mahesh","family":"Vidula","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Kondaveeti","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline A","family":"Magro","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srivinas","family":"Denduluri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"University of Pennsylvania Perelman 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