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PP naturally widens with age, but it is unclear whether the risks associated with greater PP are the same across all ages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We used Cox proportional hazards models to investigate the association of PP with (i) atherosclerotic cardiovascular disease (ASCVD) events or death and (ii) a 50% reduction in estimated glomerular filtration rate or kidney failure in the chronic renal insufficiency cohort (CRIC). We evaluated the association of time-updated PP with these outcomes, accounting for time-updated confounders using inverse probability weighting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 5,621 participants with CKD, every 10-mmHg greater PP was associated with a 6% higher risk of an ASCVD event or death (hazard ratio [HR]\u2005=\u20051.06, 95% CI 1.04, 1.08) and 17% higher risk of the composite kidney outcome (HR\u2005=\u20051.17, 95% CI 1.16, 1.18). Greater PP was associated with a higher risk of ASCVD events or death among participants in the lowest age tertile (21\u201361 years), but a higher risk of the composite kidney outcome in the oldest age tertile (71\u201379 years). While wide PP in participants that experienced the primary outcomes was predominantly driven by elevated SBP, PP remained significantly associated with the composite kidney outcome across all ages and with ASCVD events or death in the first age tertile when SBP was added to the Cox regression model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our findings suggest that the mechanism by which PP is associated with adverse outcomes may differ by age.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae136","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T20:14:07Z","timestamp":1729628047000},"page":"129-138","source":"Crossref","is-referenced-by-count":4,"title":["Pulse Pressure and Cardiovascular and Kidney Outcomes by Age in the Chronic Renal Insufficiency Cohort 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,","place":["USA"]},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University and Medical Institutions , Baltimore, MD ,","place":["USA"]},{"name":"Division of General Internal Medicine, Johns Hopkins School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-9253","authenticated-orcid":false,"given":"Paul","family":"Drawz","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of Minnesota Medical School , Minneapolis, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-079X","authenticated-orcid":false,"given":"Jordana B","family":"Cohen","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 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