{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:17:48Z","timestamp":1789103868640,"version":"build-2803163510"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shanghai Municipal Education Commission\u2014Gaofeng Clinical Medicine","award":["20172004"],"award-info":[{"award-number":["20172004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Time in target range (TTR) of systolic blood pressure (SBP) is a concept characterizing the extent of blood pressure (BP) control. We aimed to compare the risk of all-cause mortality and cardiovascular diseases (CVDs) in participants with &amp;gt;50% time of their SBP within different target ranges.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A total of 40,914 participants who had complete BP data and were free of CVDs or cancer were included. Four SBP records over 6 years were used to calculate TTR and mean levels of covariates. The death and CVD events were recorded via reviewing medical records and death certificates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>During a median follow-up period of 8.78 (interquartile range: 8.50\u20139.05) and 7.76 (interquartile range: 7.46\u20138.04) years, we identified 2,398 death cases and 1,995 incident CVDs, respectively. Participants who had &amp;gt;50% TTR &amp;gt;150 mm Hg had a higher risk of all-cause mortality (hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.16, 2.41) than those with &amp;gt;50% TTR &amp;lt;120 mm Hg. The corresponding HR was 2.06 (95% CI: 1.37, 3.10) for incident CVDs. The increased risk of all-cause mortality and CVD events persisted when we adjusted the covariates measured at the 2012 visit or excluded coalminers, the hypotensive participants, the incident cases occurring the first 2 years, or who used BP-lowering drugs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our study suggested that &amp;gt;50% TTR in a high target range of SBP significantly predicted the occurrence of all-cause mortality and CVDs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae144","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:33:32Z","timestamp":1739424812000},"page":"537-543","source":"Crossref","is-referenced-by-count":2,"title":["Time in Target Range, All-Cause Mortality, and Cardiovascular 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