{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:47:36Z","timestamp":1788929256458,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation program under the ERA-Net Cofound action","award":["N\u00b0 727565"],"award-info":[{"award-number":["N\u00b0 727565"]}]},{"name":"German Ministry of Education and Research","award":["01EA1801A"],"award-info":[{"award-number":["01EA1801A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Arterial hypertension is a significant risk factor for cardiovascular (CV) morbidity and mortality. Although central blood pressure (BP) evaluation is considered the gold standard, the reliability of non-invasive measurements remains unclear. Therefore, we compared the predictive value of invasively measured central BP with non-invasively measured brachial BP and analyzed pulse pressure (PP) amplification (delta-PP; the difference between central and peripheral PP) as an independent predictor of mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We analyzed systolic BP (SBP), diastolic BP (DBP), mean arterial BP (MAP), PP, and delta-PP as predictors of CV and all-cause mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, involving 3,316 patients referred for coronary angiography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>All brachial BP parameters, except DBP, were significantly linked to all-cause and CV mortality in a univariate analysis. A 10 mm Hg increase in SBP, MAP, and PP corresponded to increased risks of all-cause (11%, 10%, and 19%) and CV mortality (11%, 11%, and 18%). Central SBP and PP showed similar, but numerically weaker, associations with increased risks of all-cause (5% and 10%) and CV mortality (4% and 8%). After adjusting for age, sex, body mass index, diabetes mellitus, and eGFR, only delta-PP independently predicted mortality with a 10 mm Hg increase linked to a 4% reduction in all causes and a 6% reduction in CV mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Neither brachial nor centrally measured BP parameters were independent mortality predictors in contrast to PP amplification, which remained an independent predictor of mortality in multivariate analysis, in a cohort with a medium to high CV risk profile. As PP amplification decreased, mortality increased.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae156","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:54:34Z","timestamp":1734612874000},"page":"272-279","source":"Crossref","is-referenced-by-count":3,"title":["Central vs. Brachial Blood Pressure and Pulse Pressure Amplification for Mortality Risk Prediction in Patients Undergoing Coronary Angiography"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0388-3098","authenticated-orcid":false,"given":"Clara","family":"Daschner","sequence":"first","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-7275","authenticated-orcid":false,"given":"Marcus E","family":"Kleber","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]},{"name":"Synlab Academy, SYNLAB Holding Deutschland GmbH , Mannheim and Augsburg, Baden-W\u00fcrttemberg and Bayern ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3436-5969","authenticated-orcid":false,"given":"Niklas","family":"Ayasse","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-7659","authenticated-orcid":false,"given":"Ksenija","family":"Stach","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-5052","authenticated-orcid":false,"given":"Faeq","family":"Husain-Syed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen , Giessen, Hessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-0935","authenticated-orcid":false,"given":"Alexander","family":"Niessner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna , Vienna ,","place":["Austria"]},{"name":"Second Medical Department with Cardiology and Intensive Care Medicine, Klinik Landstrasse , Vienna, Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Third department of Medicine, Hospital Darmstadt , Darmstadt, Hessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-8946","authenticated-orcid":false,"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]},{"name":"Synlab Academy, SYNLAB Holding Deutschland GmbH , Mannheim and Augsburg, Baden-W\u00fcrttemberg and Bayern ,","place":["Germany"]},{"name":"Department of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Graz, Steiermark ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-2918","authenticated-orcid":false,"given":"Bernhard K","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]},{"name":"Center for Preventive Medicine Baden-W\u00fcrttemberg (CPMBW), Medical Faculty Mannheim, Heidelberg University , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]},{"name":"European Center for Angioscience ECAS, Faculty of Medicine of the University of Heidelberg , Mannheim, Baden-W\u00fcrttembarg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine, Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM , Mannheim, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"2025041505523520000_CIT0001","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/j.jacc.2019.10.009","article-title":"The global burden of cardiovascular diseases and risk factors: 2020 and beyond","volume":"74","author":"Mensah","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025041505523520000_CIT0002","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1161\/HYPERTENSIONAHA.120.15761","article-title":"Association of cardiovascular risk factors and lifestyle behaviors with hypertension: a Mendelian randomization study","volume":"76","author":"van Oort","year":"2020","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0003","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","article-title":"Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis","volume":"387","author":"Ettehad","year":"2016","journal-title":"Lancet"},{"key":"2025041505523520000_CIT0004","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"key":"2025041505523520000_CIT0005","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.CIR.100.4.354","article-title":"Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study","volume":"100","author":"Franklin","year":"1999","journal-title":"Circulation"},{"key":"2025041505523520000_CIT0006","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1161\/HYPERTENSIONAHA.123.20963","article-title":"Impact of preprocedural diastolic blood pressure on outcomes in patients undergoing percutaneous coronary intervention","volume":"80","author":"Warren","year":"2023","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0007","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/eurheartj\/ehi467","article-title":"Importance of arterial pulse pressure as a predictor of coronary heart disease risk in PROCAM","volume":"26","author":"Assmann","year":"2005","journal-title":"Eur Heart J"},{"key":"2025041505523520000_CIT0008","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/jch.14593","article-title":"The renin\u2013angiotensin\u2013aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC","volume":"24","author":"Yazdani","year":"2022","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2025041505523520000_CIT0009","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1053\/j.jvca.2023.04.024","article-title":"Central versus peripheral arterial pressure monitoring in patients undergoing cardiac surgery: a prospective observational study","volume":"37","author":"Jacquet-Lagreze","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2025041505523520000_CIT0010","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/HYPERTENSIONAHA.114.03361","article-title":"Association of central and peripheral blood pressures with intermediate cardiovascular phenotypes","volume":"63","author":"Roman","year":"2014","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0011","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1111\/jch.14067","article-title":"Association of double product and pulse pressure with cardiovascular and all-cause mortality in the LURIC study","volume":"22","author":"Yazdani","year":"2020","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2025041505523520000_CIT0012","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/ajh\/hpz100","article-title":"Association between intra-arterial invasive central and peripheral blood pressure and endothelial function (assessed by flow-mediated dilatation) in stable coronary artery disease","volume":"32","author":"Park","year":"2019","journal-title":"Am J Hypertens"},{"key":"2025041505523520000_CIT0013","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/ajh.2007.89","article-title":"Pulse pressure amplification and risk of cardiovascular disease","volume":"21","author":"Nijdam","year":"2008","journal-title":"Am J Hypertens"},{"key":"2025041505523520000_CIT0014","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.ATV.0000160548.78317.29","article-title":"Mechanisms, pathophysiology, and therapy of arterial stiffness","volume":"25","author":"Zieman","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025041505523520000_CIT0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/HYPERTENSIONAHA.109.134379","article-title":"Role of pulse pressure amplification in arterial hypertension: experts\u2019 opinion and review of the data","volume":"54","author":"Avolio","year":"2009","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0016","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.105.595496","article-title":"Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study","volume":"113","author":"Williams","year":"2006","journal-title":"Circulation"},{"key":"2025041505523520000_CIT0017","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/HYPERTENSIONAHA.120.16163","article-title":"Prediction of cardiovascular events by Type I central systolic blood pressure: a prospective study","volume":"77","author":"Lamarche","year":"2021","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0018","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/cvr\/21.9.678","article-title":"Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries","volume":"21","author":"Kawasaki","year":"1987","journal-title":"Cardiovasc Res"},{"key":"2025041505523520000_CIT0019","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/01.ATV.13.1.90","article-title":"Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries","volume":"13","author":"Benetos","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"2025041505523520000_CIT0020","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1517\/14622416.2.1.S1","article-title":"Rationale and design of the LURIC study\u2014a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease","volume":"2","author":"Winkelmann","year":"2001","journal-title":"Pharmacogenomics"},{"key":"2025041505523520000_CIT0021","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/eurheartj\/ehm037","article-title":"How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology","volume":"28","author":"Paulus","year":"2007","journal-title":"Eur Heart J"},{"key":"2025041505523520000_CIT0022","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.kint.2023.10.016","article-title":"Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns","volume":"105","author":"Levin","year":"2024","journal-title":"Kidney Int"},{"key":"2025041505523520000_CIT0023","author":"Healthcare","journal-title":"X4 Smart - Omron Deutschland [Internet]"},{"key":"2025041505523520000_CIT0024","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/VHRM.S72438","article-title":"Validation of two automatic devices for the self-measurement of blood pressure according to the ANSI\/AAMI\/ISO81060-2:2009 guidelines: the Omron BP765 (HEM-7311-ZSA) and the Omron BP760N (HEM-7320-Z)","volume":"11","author":"Takahashi","year":"2015","journal-title":"Vasc Health Risk Manag"},{"key":"2025041505523520000_CIT0025","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1161\/CIRCULATIONAHA.111.060319","article-title":"Hemodynamics in the cardiac catheterization laboratory of the 21st century","volume":"125","author":"Nishimura","year":"2012","journal-title":"Circulation"},{"key":"2025041505523520000_CIT0026","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jacc.2012.04.055","article-title":"Mortality and cardiovascular events are best predicted by low central\/peripheral pulse pressure amplification but not by high blood pressure levels in elderly nursing home subjects: the PARTAGE (Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population) study","volume":"60","author":"Benetos","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2025041505523520000_CIT0027","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jacc.2009.09.061","article-title":"Pulse pressure amplification a mechanical biomarker of cardiovascular risk","volume":"55","author":"Benetos","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2025041505523520000_CIT0028","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/hy0202.098325","article-title":"Central pulse pressure and mortality in end-stage renal disease","volume":"39","author":"Safar","year":"2002","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0029","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/eurheartj\/ehq024","article-title":"Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis","volume":"31","author":"Vlachopoulos","year":"2010","journal-title":"Eur Heart J"},{"key":"2025041505523520000_CIT0030","doi-asserted-by":"crossref","first-page":"A071","DOI":"10.1161\/hyp.80.suppl_1.071","article-title":"Abstract 071: seated and supine blood pressure and risk of cardiovascular disease and mortality from the atherosclerosis risk in communities study","volume":"80","author":"Giao","year":"2023","journal-title":"Hypertension"},{"key":"2025041505523520000_CIT0031","doi-asserted-by":"crossref","first-page":"e2023055","DOI":"10.4178\/epih.e2023055","article-title":"Association of blood pressure measurements in sitting, supine, and standing positions with the 10-year risk of mortality in Korean adults","volume":"45","author":"Baik","year":"2023","journal-title":"Epidemiol Health"},{"key":"2025041505523520000_CIT0032","doi-asserted-by":"crossref","first-page":"e13587","DOI":"10.1111\/eci.13587","article-title":"Feasibility of non-invasive measurement of central blood pressure and arterial stiffness in shock","volume":"51","author":"Markakis","year":"2021","journal-title":"Eur J Clin Invest"},{"key":"2025041505523520000_CIT0033","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/HJH.0000000000002237","article-title":"Accuracy of fully automated oscillometric central aortic blood pressure measurement techniques","volume":"38","author":"Gotzmann","year":"2020","journal-title":"J Hypertens"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpae156\/61236109\/hpae156.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/38\/5\/272\/61236109\/hpae156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/38\/5\/272\/61236109\/hpae156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T05:52:48Z","timestamp":1744696368000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/38\/5\/272\/7928547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,12,19]]},"published-print":{"date-parts":[[2025,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpae156","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2024,12,19]]}}}