{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T06:10:09Z","timestamp":1742191809593,"version":"3.38.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Leptin is a hormone that is secreted by the adipocytes. In the circulation, leptin levels are directly proportional to the body fat percentage. Studies have shown that higher leptin levels are associated with an increased risk of hypertension after adjusting for body mass index (BMI). Therefore, leptin has been proposed as a mediator of obesity-related hypertension. Whether leptin is associated with hypertension when controlling for body fat percentage remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We studied 103 obese men (BMI \u2265 30.0 kg\/m2). All men were healthy and were medication-free. We measured blood pressure using 24-h ambulatory blood pressure (ABP) recordings. Hypertension was defined as 24-h systolic ABP \u2265 130 mm Hg and\/or 24-h diastolic ABP \u2265 80 mm Hg, and normotension was defined as 24-h ABP &amp;lt; 130\/80 mm Hg. We measured fasting serum leptin concentrations and used dual-energy X-ray absorptiometry scanning to determine body fat percentage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 103 obese men, 64 were hypertensive (24-h systolic ABP\u2014mean \u00b1 standard deviation\u2014137\u2005\u00b1\u200511 mg Hg and 24-h diastolic ABP 83\u2005\u00b1\u20056 mm Hg) and 40 were normotensive (24-h systolic ABP 117\u2005\u00b1\u20056 mg Hg and 24-h diastolic ABP 73\u2005\u00b1\u20054 mm Hg). The 2 groups had similar fasting serum leptin concentrations (median\u2014interquartile range; 13.4 (5.7\u201336.1) \u00b5g\/L vs. 13.4 (5.4-27.1) \u00b5g\/L, P\u2005=\u20050.88) and total fat mass percentage (34.8\u2005\u00b1\u20054.5% vs. 34.0\u2005\u00b1\u20054.7%, P\u2005=\u20050.90).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Obese hypertensive men have serum leptin concentrations similar to those of obese normotensive men with comparable body fat percentage measurements. This finding does not support leptin\u2019s candidacy as a mediator of obesity-related hypertension.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf007","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T17:16:46Z","timestamp":1736529406000},"page":"233-239","source":"Crossref","is-referenced-by-count":0,"title":["Obese Hypertensive Men Have Fasting Serum Concentrations of Leptin Similar to Those of Obese Normotensive Men"],"prefix":"10.1093","volume":"38","author":[{"given":"Camilla L","family":"Asferg","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital , Roskilde ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik B","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet Glostrup , Glostrup ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-0961","authenticated-orcid":false,"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital , Odense ,","place":["Denmark"]},{"name":"Department of Clinical Research, Faculty of Health, University of Southern Denmark , Odense ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-0184","authenticated-orcid":false,"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital , Copenhagen 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