{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:12:42Z","timestamp":1787497962368,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Hypertension (HTN) has been demonstrated as one of the leading risk factors for development of cardiovascular disease (CVD) and CVD mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This study examines the prevalence and distribution of HTN subtypes (isolated diastolic hypertension [IDH], isolated systolic hypertension [ISH], and systolic-diastolic hypertension [SDH]) across age, sex, and race\/ethnicity per the nationally representative National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020 based on the updated 2017 ACC\/AHA HTN definition. We further examined for associations of each subtype with CVD and all-cause mortality using Cox regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among US adults, the overall prevalence of HTN is 47.4%. Across increasing age, the prevalence of IDH decreased, ISH increased, and SDH increased and peaked in the 6th decade of life after which SDH prevalence decreased. By age 80, over 80% of persons with HTN demonstrated ISH. A subcohort from NHANES 1999\u20132008 with follow-up until 2018 showed that ISH and SDH were most strongly associated with increased risk for CVD (HR\u2005=\u20051.18, 95% CI, 1.01\u20131.38; HR\u2005=\u20051.31, 95% CI, 1.07\u20131.60, respectively) and all-cause mortality (HR\u2005=\u20051.17, 95% CI, 1.06\u20131.28; HR\u2005=\u20051.21, 95% CI, 1.08\u20131.37, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Our data demonstrate the continuing importance of HTN subtype transitions across age and their differences in predicting future CVD and total mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf010","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T07:28:38Z","timestamp":1738222118000},"page":"303-312","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and Mortality Trends of Hypertension Subtypes Among US Adults: An Analysis of the National Health and Nutrition Examination Survey"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4160-1868","authenticated-orcid":false,"given":"Kevin S","family":"Tang","sequence":"first","affiliation":[{"name":"Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, Department of Medicine, University of California , Irvine, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E","family":"Jones","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, Department of Medicine, University of California , Irvine, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Fan","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, Department of Medicine, University of California , Irvine, CA ,","place":["USA"]},{"name":"Department of Epidemiology and Biostatistics, University of California , Irvine, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-7324","authenticated-orcid":false,"given":"Nathan D","family":"Wong","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, Department of Medicine, University of California , Irvine, CA ,","place":["USA"]},{"name":"Department of Epidemiology and Biostatistics, University of California , Irvine, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"key":"2025041505531104200_CIT0001","doi-asserted-by":"publisher","first-page":"9376134","DOI":"10.1155\/2021\/9376134","article-title":"Hypertension and the risk of all-cause and cause-specific 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