{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:29:40Z","timestamp":1771637380023,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Heart failure (HF) and cognitive impairment often occur together in older adults. Although earlier studies have reported an association between blood pressure (BP) variability (BPV) and cognitive impairment, the underlying pathophysiology remains unclear in HF. In this study, the hypothesis that higher BPV is associated with cognitive impairment was evaluated in the elderly patients with acute decompensated HF (ADHF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Day-to-day in-hospital BPV and cognitive function using a mini-mental state examination (MMSE) were assessed in 245 elderly patients (82.9\u2005\u00b1\u20056.0 years, 49.4% male) with ADHF. Based on the data of 7 days, day-to-day BPV (expressed as the standard deviation [SD], coefficient of variation [CV], maximum BP, minimum BP, and \u03b4 [maximum-minimum] BP) were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>According to MMSE score quartiles, significant differences were observed in SD (8.2 vs. 6.2 vs. 6.7 mmHg, P\u2005&amp;lt;\u20050.001), CV (13.3 vs. 9.94 vs. 10.9 %, P\u2005&amp;lt;\u20050.001) and \u03b4 (22.8 vs. 17.5 vs. 18.6 mmHg, P\u2005&amp;lt;\u20050.001) in diastolic BP (DBP) between three groups. In the logistic regression analysis adjusted for the confounders, SD (OR: 1.23, P\u2005&amp;lt;\u20050.01), CV (OR: 1.12, P\u2005&amp;lt;\u20050.01), maximum (OR: 1.13, P\u2005&amp;lt;\u20050.001) and \u03b4 (OR: 1.07, P\u2005&amp;lt;\u20050.01) in DBP were significantly associated with the lowest quartile of MMSE score. In the stratified analysis by HF phenotypes, significant associations of day-to-day DBP variability were found with the lowest quartile of MMSE score specifically in the HF with preserved ejection fraction group (HFpEF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Cognitive impairment in association with day-to-day BPV is increasingly prevalent in elderly patients presenting with ADHF, specifically in HFpEF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf030","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:32:42Z","timestamp":1741743162000},"page":"439-449","source":"Crossref","is-referenced-by-count":2,"title":["Day-to-Day Blood Pressure Variability and Cognitive Function in the Elderly With Acute Heart Failure"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-1369","authenticated-orcid":false,"given":"Michiaki","family":"Nagai","sequence":"first","affiliation":[{"name":"Cardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center , Oklahoma ,","place":["USA"]},{"name":"Department of Cardiology, Hiroshima City Asa Hospital , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Dote","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hiroshima City Asa Hospital , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hiroshima City Asa Hospital , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faddi G","family":"Saleh Velez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Oklahoma Health Science Center , Oklahoma ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Dasari","sequence":"additional","affiliation":[{"name":"Cardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center , Oklahoma ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"2025062507135354100_CIT0001","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(10)60309-1","article-title":"Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension","volume":"375","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"key":"2025062507135354100_CIT0002","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(10)60308-X","article-title":"Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension","volume":"375","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"key":"2025062507135354100_CIT0003","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cardfail.2024.01.003","article-title":"HFSA Scientific Statement Committee Members. 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