{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:50:02Z","timestamp":1792795802151,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99\/R00 HL138133"],"award-info":[{"award-number":["K99\/R00 HL138133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The University of Iowa Graduate College"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Women with a history of preeclampsia are at increased risk of developing cardiovascular disease compared with women who had a healthy pregnancy. One potential mechanism underlying this increased risk is microvascular endothelial dysfunction, characterized by reduced nitric oxide (NO)-dependent dilation and is mediated, in part, by increased vasoconstrictor sensitivity to angiotensin II, which persists postpartum. We hypothesized that systemic angiotensin II type 1 receptor (AT1R) inhibition via once-daily oral losartan treatment would (1) improve endothelium- and NO-dependent dilation, and (2) reduce angiotensin II-mediated vasoconstriction, in the microvasculature of women with a history of preeclampsia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Eleven normotensive women, &amp;gt;12 weeks and \u22645 years postpartum, with a history of preeclampsia participated in a double-blind, placebo-controlled, crossover study. Following 6 weeks of placebo and losartan treatment (50 mg\/day), we measured cutaneous vascular conductance responses to graded infusions of acetylcholine (ACh, 10\u221210\u201310\u22121 M) alone or with 15 mM NG-nitro-l-arginine methyl ester (L-NAME; NO-synthase inhibitor) to assess endothelium- and NO-dependent dilation, respectively. We also assessed microvascular vasoconstrictor responses to graded infusions of angiotensin II (10\u221220\u201310\u22124 M) and norepinephrine (10\u221212\u201310\u22122 M).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Losartan treatment increased endothelium- (P\u2005&amp;lt;\u20050.001) and NO-dependent (P\u2005&amp;lt;\u20050.016) vasodilation compared with placebo. Losartan treatment also reduced angiotensin II-mediated vasoconstriction (P\u2005&amp;lt;\u20050.001) compared with placebo, but had no effect on norepinephrine-mediated vasoconstriction (P\u2005=\u20050.46).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These data suggest that systemic AT1R-inhibition with oral losartan is a viable, mechanism-specific approach to improve endothelial function and reduce vasoconstrictor sensitivity to angiotensin II in the microvasculature of healthy, normotensive women with a history of preeclampsia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf033","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T05:43:13Z","timestamp":1741844593000},"page":"459-466","source":"Crossref","is-referenced-by-count":8,"title":["Oral Losartan Treatment Improves Microvascular Endothelial Function via Nitric Oxide-Dependent Mechanisms in Women With a History of Preeclampsia"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-1813","authenticated-orcid":false,"given":"Kelsey S","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Health and Human Physiology, The University of Iowa , Iowa City, Iowa ,","place":["USA"]},{"name":"Department of Internal Medicine, Carver College of Medicine , Iowa City, Iowa ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-8650","authenticated-orcid":false,"given":"Diana I","family":"Jalal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine , Iowa City, Iowa ,","place":["USA"]},{"name":"The Iowa City VA HCS , Iowa City, Iowa 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