{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:03:41Z","timestamp":1793315021139,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Adrenal artery embolization (AAE) has been shown to reduce blood pressure (BP) and correct biochemical abnormalities in patients with idiopathic hyperaldosteronism (IHA) during short-term 6\u201312-month follow-ups. This study aimed to evaluate the long-term efficacy and safety of unilateral AAE over a 24-month period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The prospective study included 109 IHA patients undergoing unilateral AAE, with 94 completing the 24-month follow-up. Evaluations included office, home and 24-hour ambulatory BP, biochemical markers, renal function, and cardiac function (echocardiography). Medication use and adverse events were documented.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>At the 24-month follow-up, the office, home, and 24-hour ambulatory systolic BP values decreased by 17.3\u2005\u00b1\u200523.1, 16.4\u2005\u00b1\u200521.9, and 9.9\u2005\u00b1\u200518.6 mmHg, respectively (all P\u2005&amp;lt;\u20050.001), and the diastolic BP values decreased by 8.8\u2005\u00b1\u200516.1, 7.1\u2005\u00b1\u200515.8, and 6.4\u2005\u00b1\u200511.1 mmHg (all P\u2005&amp;lt;\u20050.001). The complete and partial clinical success rates were 14.9% and 50.0%, respectively, whereas those for biochemical success were 13.6% and 45.5%. Abnormal biochemical characteristics, including elevated plasma aldosterone levels, increased aldosterone\u2012renin ratios (ARRs), plasma renin suppression, and hypokalemia, were significantly improved (all P\u2005&amp;lt;\u20050.01). Improvements in cardiac remodeling and left ventricular (LV) diastolic function were observed, particularly in those with elevated LV mass index (P\u2005&amp;lt;\u20050.05). No evidence of renal impairment or long-term safety concerns was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Unilateral AAE in IHA patients promotes sustained BP reduction, biochemical correction, improved cardiac remodeling, and enhanced LV diastolic function over 24 months, with no significant long-term safety concerns.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf077","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T09:27:49Z","timestamp":1746178069000},"page":"675-685","source":"Crossref","is-referenced-by-count":5,"title":["Long-term Efficacy and Safety of Unilateral Adrenal Artery Embolization in Patients with Idiopathic Hyperaldosteronism: A 24-month Cohort Study"],"prefix":"10.1093","volume":"38","author":[{"given":"Guo","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Cardiology, School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College , Chengdu, Sichuan 610500 ,","place":["China"]},{"name":"Key Laboratory of Aging and Vascular Homeostasis at Chengdu Medical College of Sichuan Province , Chengdu, Sichuan ,","place":["China"]},{"name":"Clinical Research Center for Geriatrics of Sichuan Province , Chengdu, Sichuan ,","place":["China"]},{"name":"School of Clinical Medicine, Chengdu Medical College , Chengdu, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College , Chengdu, Sichuan 610500 ,","place":["China"]},{"name":"Key Laboratory of Aging and Vascular Homeostasis at Chengdu Medical College of Sichuan Province , Chengdu, Sichuan ,","place":["China"]},{"name":"Clinical Research Center for Geriatrics of Sichuan Province , 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