{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:50Z","timestamp":1788561410093,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060990"],"award-info":[{"award-number":["U01DK060990"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060984"],"award-info":[{"award-number":["U01DK060984"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK061022"],"award-info":[{"award-number":["U01DK061022"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK061021"],"award-info":[{"award-number":["U01DK061021"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK061028"],"award-info":[{"award-number":["U01DK061028"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060980"],"award-info":[{"award-number":["U01DK060980"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060963"],"award-info":[{"award-number":["U01DK060963"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060902"],"award-info":[{"award-number":["U01DK060902"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U24DK060990"],"award-info":[{"award-number":["U24DK060990"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Patients with chronic kidney disease (CKD) have abnormal blood pressure patterns which may affect 24-hour ambulatory blood pressure variability (ABPV). However, little is known about the association between ABPV and adverse outcomes among those with CKD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Using data from the Chronic Renal Insufficiency Cohort (CRIC) Study, we assessed 24-hour, daytime, and nighttime systolic ABPV using average real-time variability (ARV); the sum of the absolute differences between consecutive blood pressure readings divided by the total number of readings minus one. Cox proportional hazard models were used to evaluate the association of ARV with a 50% reduction in estimated glomerular filtration rate or end-stage kidney disease or adverse cardiovascular (CV) events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 1,502 CRIC participants included in this analysis, 44% were female, and the mean age was 63\u2005\u00b1\u200510 years. Factors associated with higher tertile of ARV included older age, higher body mass index, higher urine protein-to-creatinine ratio, lower estimated glomerular filtration rate, diabetes, hypertension, dyslipidemia, and atherosclerotic heart disease. In unadjusted models, 24-hour systolic ARV was associated with both adverse kidney outcomes (hazard ratio (HR): 1.16, 95% confidence interval (CI): 1.06\u20131.27) and CV events (HR: 1.35, 95% CI: 1.22\u20131.50). In adjusted models that included clinical and sociodemographic factors, 24-hour systolic ARV was not significantly associated with adverse kidney outcomes (HR: 1.02, 95% CI: 0.91\u20131.14) or CV events (HR: 0.93, 95% CI: 0.84\u20131.04). Similarly, daytime and nighttime ARV were not significantly associated with kidney and CV events in adjusted analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In a large cohort of patients with CKD, ABPV was not independently associated with adverse kidney and CV outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf102","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T12:41:56Z","timestamp":1751028116000},"page":"957-963","source":"Crossref","is-referenced-by-count":4,"title":["Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-7118","authenticated-orcid":false,"given":"Rushelle 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Hypertension Division, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alavi","family":"Hossain","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-8834","authenticated-orcid":false,"given":"Daichi","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Columbia Hypertension Laboratory, Department of Medicine, Columbia University Irving Medical Center , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-079X","authenticated-orcid":false,"given":"Jordana B","family":"Cohen","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension 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