{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:07:25Z","timestamp":1785150445067,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Umbra Cuore e Ipertensione"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Different definitions of white-coat hypertension (WCH) may explain its variable outcome across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In an Italian study started in 1986, we followed 3,153 people with (office blood pressure (BP) &amp;gt;=140\/90 mmHg) and 457 without office hypertension for a mean of 10.4 years. None had previous cardiovascular disease. All underwent 24-h ambulatory BP (ABP) monitoring. We defined white-coat hypertension (WCH) as an average 24-h ABP\u2005&amp;lt;\u2005130\/80 mmHg or &amp;lt;125\/75 mmHg. The primary outcome was a composite of major adverse cardiovascular events (MACE) and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Baseline office BP was 156\/97 mmHg in people with and 127\/81 mmHg without hypertension. At follow-up, MACE events were 344 and 23, and all-cause deaths were 318 and 24 in people with and without hypertension, respectively. Compared to normotensive group, MACE risk was not higher in people with WCH and 24-h ABP\u2005&amp;lt;\u2005125\/75 mmHg (hazard ratio (HR), 0.94; 95% confidence interval (CI), 0.42\u20132.10). Compared to normotensive group, MACE risk was higher in people with WCH and 24-h ABP\u2005&amp;lt;\u2005130\/80 mmHg (HR: 1.79; 95% CI, 1.07\u20132.29). All-cause death did not differ between the normotensive group and people with WCH and 24-h ABP\u2005&amp;lt;\u2005125\/75 mmHg (HR 1.37; 95% CI, 0.68\u20132.73), but it was higher than in the normotensive group when WCH was defined by a 24-h ABP\u2005&amp;lt;\u2005130\/80 mmHg (HR 1.82; 95% CI, 1.55\u20133.58).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>WCH defined by an average 24-h ABP\u2005&amp;lt;\u2005125\/75 mmHg identifies people at low risk of MACE and death in the long term. Even modestly above these threshold values, the risk associated with WCH increases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf136","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:09:32Z","timestamp":1752746972000},"page":"1043-1050","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Impact of Different Definitions of White-Coat Hypertension"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4135-8936","authenticated-orcid":false,"given":"Paolo","family":"Verdecchia","sequence":"first","affiliation":[{"name":"Associazione Umbra Cuore e Ipertensione and Division of Cardiology, Hospital S. Maria della Misericordia , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Coiro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital S. Maria della Misericordia , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital S. Maria della Misericordia , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Aita","sequence":"additional","affiliation":[{"name":"Departimento di Medicina,Unit\u00e0 Sanitaria Locale\u2019Umbria 1\u2019 , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Borgioni","sequence":"additional","affiliation":[{"name":"Departimento di Medicina,Unit\u00e0 Sanitaria Locale\u2019Umbria 1\u2019 , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Repaci","sequence":"additional","affiliation":[{"name":"Departimento di Medicina,Unit\u00e0 Sanitaria Locale\u2019Umbria 1\u2019 , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Dembech","sequence":"additional","affiliation":[{"name":"Departimento di Medicina, Ospedale di Castiglione del Lago , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Guerrieri","sequence":"additional","affiliation":[{"name":"Departimento di Medicina, Ospedale di Castiglione del Lago , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Departimento di Medicina, Ospedale di Castiglione del Lago , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Bistoni","sequence":"additional","affiliation":[{"name":"Departimento di Medicina, Ospedale di Assisi , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Trottini","sequence":"additional","affiliation":[{"name":"Departimento di Medicina, Ospedale di Assisi , Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-7985","authenticated-orcid":false,"given":"Fabio","family":"Angeli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Technological Innovation (DiMIT), University of Insubria , Varese ,","place":["Italy"]},{"name":"Department of Medicine and Cardiopulmonary Rehabilitation, Maugeri Care and Research Institute, IRCCS Tradate , Tradate ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"2025111618561957000_CIT0001","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.HYP.24.6.793","article-title":"Ambulatory blood pressure. 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