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It varies over intervals from months to consecutive cardiac cycles, and this variation contains meaningful information beyond mean BP. Variability over multiple clinic visits (VVV-BP) and during 24-h ambulatory monitoring (ABPV) is positively related to risk of stroke and coronary artery disease and negatively associated with cognitive performance. Beat-to-beat BP variation, often quantified as low frequency variability (0.04\u20130.15 Hz, LF-BPV), is less well-studied. Here, we examine the relationship between LF-BPV and cognitive outcomes in 1953 participants from the Midlife in the US study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Participants completed the Brief Test of Adult Cognition by Telephone from which we derived episodic memory (EMF) and executive function (EFF) factors and a composite index. With participants in the seated position, the continuous BP signal was recorded noninvasively with a Finometer. The resultant time series was submitted to Fourier-based spectral analysis to compute LF-BPV. Linear regression models estimated the associations with cognitive indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Systolic (LF-SBPV) and diastolic (LF-DBPV) were positively associated with EFF (b\u2005=\u20050.073\u2005\u00b1\u20050.033, P\u2005=\u20050.02), EMF (b\u2005=\u20050.079\u2005\u00b1\u20050.036, P\u2005=\u20050.04), and the composite index (b\u2005=\u20050.101\u2005\u00b1\u20050.035, P\u2005=\u20050.004) after adjustment for age, sex, education, and income. Findings were similar for LF-DBPV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This positive association is consistent with evidence demonstrating that LF blood pressure variability contributes to increased delivery of oxygenated blood to the brain and clearance of metabolic and cellular waste via the brain\u2019s glymphatic system and intramural periarterial drainage pathway, both of which contribute to superior cognitive performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf165","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:32:56Z","timestamp":1756207976000},"page":"231-240","source":"Crossref","is-referenced-by-count":1,"title":["Dynamical Regulation of Blood Pressure and Cognitive Function"],"prefix":"10.1093","volume":"39","author":[{"given":"Joshua","family":"Sweigert","sequence":"first","affiliation":[{"name":"Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Gruenewald","sequence":"additional","affiliation":[{"name":"Department of Psychology, Chapman University , Orange, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-8735","authenticated-orcid":false,"given":"Margie","family":"Lachman","sequence":"additional","affiliation":[{"name":"Department of Psychology, Brandeis University , Waltham, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Seeman","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine, David Geffen School of Medicine at UCLA , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Center for Population and Health, Georgetown University , Washington, District of Columbia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse-Hwei","family":"Choo","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine, New York State Psychiatric Institute , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pavlicova","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna","family":"Mukkamala","sequence":"additional","affiliation":[{"name":"Bioengineering Department, Swanson School of Engineering, University of Pittsburgh , Pittsburgh, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-9209","authenticated-orcid":false,"given":"Richard P","family":"Sloan","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine, New York State Psychiatric Institute , New York, New York ,","place":["USA"]},{"name":"Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"2026020915215597000_CIT0001","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"2026020915215597000_CIT0002","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1212\/WNL.53.9.1948","article-title":"Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. 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