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Low-intensity statin therapy can modestly reduce blood pressure (BP). In this exploratory analysis, we examined if six months of high-intensity statin therapy could lower resting or ambulatory BP in patients with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>39 patients with OSA (13F, age\u2009=\u200949\u2009\u00b1\u20099yrs, body mass index\u2009=\u200932.9\u2009\u00b1\u20094.2kg\/m2, apnea-hypopnea index\u2009=\u200922.2\u2009\u00b1\u200912.4 events\/hour) were randomized to high-intensity atorvastatin or placebo. BP was assessed using seated, \u201coffice\u201d measurements and in 20-minute intervals over 24 consecutive hours at three timepoints (baseline, three- and six-months post-randomization). Participants maintained a diary denoting sleep and wake times for analysis. Changes (\u0394) in BP from baseline were assessed and adjusted for adherence to participants\u2019 intervention (atorvastatin or placebo) as well as to their treatment for OSA (yes or no).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no between-group differences in baseline BP variables (P\u2009=\u2009.09-.96). At three months, the changes in resting (P\u2009=\u2009.74-.87), 24 hour mean (P\u2009=\u2009.54-.96), daytime (P\u2009=\u2009.70-.96), nor nighttime (P\u2009=\u2009.74-.96) BP did not differ between groups. Similarly, the changes in resting (P\u2009=\u2009.23-.92), 24 hour mean (P\u2009=\u2009.51-.82), daytime (P\u2009=\u2009.17-.78), and nighttime (P\u2009=\u2009.51-1.00) BP did not differ between groups following six months of their respective intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that high-intensity atorvastatin does not lower resting or ambulatory BP in patients with OSA relative to a placebo. Thus, it does not appear that atorvastatin is a viable adjunct intervention for BP reduction in patients with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>URL: https:\/\/www.clinicaltrials.gov; Unique identifier: NCT03308578.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf202","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:44:51Z","timestamp":1759837491000},"page":"390-399","source":"Crossref","is-referenced-by-count":0,"title":["High-Intensity Atorvastatin and 24-Hour Blood Pressure in Obstructive Sleep Apnea: A Randomized, \u00adDouble-Blind, Placebo-Controlled Pilot Study"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-0900","authenticated-orcid":false,"given":"Joshua M","family":"Bock","sequence":"first","affiliation":[{"name":"Departments of Cardiovascular 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