{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:36:14Z","timestamp":1784133374754,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020273","name":"Korean Society of Hypertension","doi-asserted-by":"publisher","award":["KSH-R-2023"],"award-info":[{"award-number":["KSH-R-2023"]}],"id":[{"id":"10.13039\/100020273","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Cardiac Research Foundation","award":["202303-03"],"award-info":[{"award-number":["202303-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex differences in blood pressure (BP) regulation may modify associations between BP variability (BPV) and hypertension-mediated organ damage (HMOD), but organ-specific effects remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 398 hypertensive patients from a multicenter home BP monitoring registry. The office-home BP difference (\u0394BP = office\u2014home) was analyzed as a single continuous exposure variable, with positive values indicating the white-coat effect and negative values indicating the masked effect. Multivariable regression examined sex-specific associations of BPV patterns with HMOD, including electrocardiographic left ventricular hypertrophy (ECG-LVH) and microalbuminuria\/proteinuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women demonstrated higher home systolic BPV than men despite similar mean BP levels (P\u2009&amp;lt;\u2009.01). Office BP was the primary determinant of white-coat phenotypes (office SBP: adjusted odds ratio [aOR] 1.29 [95% CI: 1.22-1.37]; office DBP: aOR 1.27 [1.19-1.37], both P\u2009&amp;lt;\u2009.01), while home BP predicted masked phenotype (home SBP: aOR 1.23 [1.12-1.39]; home DBP: aOR 1.34 [1.23-1.48], both P\u2009&amp;lt;\u2009.01). White-coat effects showed protective associations with total HMOD (systolic aOR 0.97 [0.94-1.00], P\u2009&amp;lt;\u2009.05), while office BPV demonstrated consistent positive associations (systolic aOR 1.10 [1.05-1.16]; diastolic aOR 1.12 [1.05-1.20], both P\u2009&amp;lt;\u2009.01). Critically, significantly sex interaction emerged for ECG-LVH, while microalbuminuria\/proteinuria showed consistent associations across sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sex fundamentally modifies BP patterns-HMOD relationships in an organ-specific manner. Cardiac target organ damage requires sex-attentive monitoring approaches, while renal damage shows universal associations with office BPV. These findings support precision medicine approaches to hypertension management incorporating sex-specific BP assessment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf212","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:28:16Z","timestamp":1760959696000},"page":"505-513","source":"Crossref","is-referenced-by-count":1,"title":["Sex Differences in Blood Pressure Variability, Office-Home Difference, and Hypertension-Mediated Organ Damage: A Multicenter Analysis"],"prefix":"10.1093","volume":"39","author":[{"given":"Jung-Joon","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Cardiology, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Won","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-9082","authenticated-orcid":false,"given":"Dong-Hyuk","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-5122","authenticated-orcid":false,"given":"Mi-Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yong","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Korea University Ansan Hospital , Ansan,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-6267","authenticated-orcid":false,"given":"Eung Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Korea University Guro Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-8464","authenticated-orcid":false,"given":"Hyung Joon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Korea University Anam Hospital , Seoul,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2026031200563362600_hpaf212-B1","doi-asserted-by":"crossref","first-page":"e029297","DOI":"10.1161\/JAHA.122.029297","article-title":"Blood pressure variability in clinical practice: past, present and the future","volume":"12","author":"Sheikh","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2026031200563362600_hpaf212-B2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/HJH.0000000000003994","article-title":"Blood pressure variability: a review","volume":"43","author":"Kulkarni","year":"2025","journal-title":"J 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perspectives","volume":"35","author":"Niiranen","year":"2012","journal-title":"Hypertens Res."},{"key":"2026031200563362600_hpaf212-B21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/IBPC.S128947","article-title":"Masked hypertension and cardiovascular outcomes: an updated systematic review and meta-analysis","volume":"11","author":"Palla","year":"2018","journal-title":"Integr Blood Press Control."}],"container-title":["American Journal of 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