{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:10:36Z","timestamp":1779354636464,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"name":"Career Development","award":["IK2-CX001776"],"award-info":[{"award-number":["IK2-CX001776"]}]},{"name":"Department of Veterans Affairs Clinical Sciences Research and Development Service"},{"name":"Madison VA Hospital"},{"name":"University of Wisconsin Atherosclerosis Imaging Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Using brachial blood pressure (BP) as a surrogate for central BP when calculating carotid arterial stiffness (CAS) has not been studied in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Veterans (n\u2009=\u2009180) age 60+ were recruited from Madison VA Hospital. Resting supine brachial and central BP (estimated from radial artery waveforms, Atcor Medical) were obtained. Right common carotid diameters were measured using ultrasound (Philips CX50, L12-3 transducer) after a transverse sweep to identify plaque presence to optimize longitudinal angle of approach free of plaque. CAS (Peterson\u2019s elastic modulus [PEM], Young\u2019s elastic modulus [YEM]) and distensibility coefficient (DC) were calculated using brachial and central BP. Differences in CAS were compared using paired Wilcoxon tests. Linear regression models evaluated associations with cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants were 70.4 (7.7) years old and 27.8% were female. Average brachial systolic BP was significantly higher than central (132.3 [18.6] mm Hg vs. 123.8 [17.7] mm Hg P\u2009&amp;lt;\u2009.001). Compared to brachial BP, using central BP to calculate stiffness measures resulted in significantly lower YEM and PEM and significantly higher DC (PEM: 480.6 [209.5] mm Hg vs. 378.3 [178.4] mm Hg; YEM: 2220.2 [926.6] mm Hg vs. 1746.9 [785.4] mm Hg; DC: 2.4 [1.0] \u00d7 10\u22123 mm Hg\u22121 vs. 3.1 [1.1] \u00d7 10\u22123 mm Hg\u22121; all P\u2009&amp;lt;\u2009.001). Absence of hypertension was associated with smaller differences in PEM (\u03b2 = \u221226.02, SE\u2009=\u200912.37, P\u2009=\u2009.04), while older age was associated with greater differences in DC when calculated using brachial vs. central BP (\u03b2\u00a0 = 2.09 \u00d7 10\u22125, SE\u2009=\u20090.67 \u00d7 10\u22125, P\u2009=\u2009.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Brachial and central BP differ in older adults and result in significant differences in calculated CAS and distensibility. Brachial BP overestimates CAS, especially in hypertensive adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf234","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:44:06Z","timestamp":1765111446000},"page":"750-756","source":"Crossref","is-referenced-by-count":0,"title":["Central and Brachial Pressures: Effects on Arterial Stiffness in Older Adults"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-5939","authenticated-orcid":false,"given":"Sakar","family":"Gupta","sequence":"first","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Department of Medicine , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Hess","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Hein","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E","family":"Korcarz","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyn","family":"Nguyen","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinwale","family":"Iyeku","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy R","family":"Williams","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly A","family":"Cole","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital , Madison, WI,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Pewowaruk","sequence":"additional","affiliation":[{"name":"William S. 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