{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:03:55Z","timestamp":1784106235957,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL158790"],"award-info":[{"award-number":["R01HL158790"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood pressure (BP) variability and long-term BP exposure is associated with cardiorenal events. We investigated the associations of visit-to-visit BP variability and cumulative BP exposure with cardiorenal events in young adults with hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified adults aged 18-39 years with stage 1 or 2 hypertension between 2009 and 2019 from a large US-integrated healthcare system. BP variability was assessed using coefficient of variation, and cumulative BP exposure was calculated as the time-weighted average over 3 years prior to the index date. Cox proportional hazards models assessed associations with incident cardiovascular and kidney events, adjusting for baseline BP and covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 151,692 young adults, 812 cardiovascular and 1194 kidney events occurred over a median of 5.4 years. Both systolic BP (SBP) variability and time-weighted average SBP exhibited J-shaped or linear associations with cardiorenal events, especially among stage 1 hypertension. In this group, SBP variability at the 90th vs 50th percentile was associated with increased risks of cardiovascular (HR\u2009=\u20091.25; 95% CI, 1.07-1.46) and kidney events (HR\u2009=\u20091.24; 95% CI, 1.09-1.41), after adjusting for baseline BP. Time-weighted average SBP of 140 vs 120 mm Hg was associated with increased risks of cardiovascular (HR\u2009=\u20092.58; 95% CI, 1.82-3.65) and kidney events (HR\u2009=\u20091.56; 95% CI, 1.16-2.10). Time-weighted average diastolic BP of 90 vs 80 mm Hg was associated with cardiovascular (HR\u2009=\u20093.65; 95% CI, 2.18-6.14) and kidney events (HR\u2009=\u20091.53; 95% CI, 0.96-2.42).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BP variability and cumulative BP exposure may be important prognostic markers for cardiorenal events in young adults, particularly those with stage 1 hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaf251","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:28:28Z","timestamp":1767702508000},"page":"988-996","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular and Kidney Events Associated with Visit-to-Visit Blood Pressure Variability among Young Adults with Hypertension"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5732","authenticated-orcid":false,"given":"Jaejin","family":"An","sequence":"first","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]},{"name":"Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-0002","authenticated-orcid":false,"given":"Heidi","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Kyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerresa L","family":"Morrissette","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-1649","authenticated-orcid":false,"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA,","place":["United States"]},{"name":"Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine , Pasadena, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-6047","authenticated-orcid":false,"given":"Brandon K","family":"Bellows","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Columbia University Irving Medical Center , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E","family":"Moran","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Columbia University Irving Medical Center , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-5001","authenticated-orcid":false,"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Columbia University Irving Medical Center , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026071504094781900_hpaf251-B1","volume-title":"Hypertension Prevalence, Awareness, Treatment, and Control among Adults Age 18 and Older: United States, August 2021-August 2023. 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