{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:57:20Z","timestamp":1781621840662,"version":"3.54.5"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270463"],"award-info":[{"award-number":["82270463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Henan Provincial Department of Science and Technology","award":["251111312800"],"award-info":[{"award-number":["251111312800"]}]},{"name":"Henan Medical Science and Technology Research and Development Program"},{"name":"Provincial-Ministerial Joint Major Project","award":["SBGJ202401001"],"award-info":[{"award-number":["SBGJ202401001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nocturnal hypertension (NH) is a significant risk factor for target organ damage and all-cause mortality. Post-saline infusion test plasma aldosterone concentration (post-SIT PAC) serves as an indicator of autonomous aldosterone secretion level, but its link to NH is uncertain. This study aims to explore the association between post-SIT PAC levels and NH in patients with suspected primary aldosteronism (PA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were classified into 3 groups after a saline infusion test (SIT): negative (post-SIT PAC &amp;lt; 5 ng\/dL, n\u2009=\u200986), borderline (post-SIT PAC 5-10 ng\/dL, n\u2009=\u2009180), and positive (post-SIT PAC &amp;gt; 10 ng\/dL, n\u2009=\u200975). Restricted cubic spline (RCS) plots were used to explore the dose-response relationship between post-SIT PAC and NH, while multivariable logistic regression models adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this retrospective study, the overall prevalence of NH was 70.4%. A positive, nonlinear association was identified between post-SIT PAC and NH (P-nonlinear &amp;lt;.05). After adjustment for multiple variables, post-SIT PAC remained significantly correlated with NH (OR\u2009=\u20091.08; 95% CI: 1.01-1.15; P\u2009&amp;lt;\u2009.05), while basal PAC was not. Additionally, guideline-defined subgroups with elevated post-SIT PAC demonstrated a higher prevalence of NH (P\u2009&amp;lt;\u2009.05). Specifically, NH prevalence was 81.3% (n\u2009=\u200975) in the positive subgroup, 72.2% (n\u2009=\u2009180) in the borderline subgroup, and 57.0% (n\u2009=\u200986) in the negative subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The level of autonomous aldosterone secretion, rather than the basal aldosterone level, is relevant to potential PA patients at risk for NH. NH prevalence increases nonlinearly with higher post-SIT PAC levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpag007","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:39:25Z","timestamp":1769863165000},"page":"864-872","source":"Crossref","is-referenced-by-count":0,"title":["Association between plasma aldosterone after saline infusion test\u00a0and nocturnal hypertension in patients with suspected primary aldosteronism"],"prefix":"10.1093","volume":"39","author":[{"given":"Lulu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hypertension, Zhengzhou University People's Hospital, Henan Provincial People's Hospital , Zhengzhou, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Henan Provincial People\u2019s Hospital , Zhengzhou, 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