{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:33:54Z","timestamp":1786700034322,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260214"],"award-info":[{"award-number":["32260214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institutional Research Grant of the Second Affiliated Hospital of Nanchang University","award":["2023efyA03"],"award-info":[{"award-number":["2023efyA03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Selective adrenal arterial embolization (SAAE) is a minimally invasive, vascular intervention targeting aldosterone-producing tissue in primary aldosteronism (PA). While surgery and mineralocorticoid receptor antagonists are standard therapies, long-term cardiac outcomes after SAAE remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 129 patients with adrenal vein sampling\u2014confirmed unilateral PA who declined adrenalectomy underwent SAAE. Biochemical outcomes were classified by Primary Aldosteronism Surgical Outcome (PASO) criteria as complete (CS, n\u2009=\u200971) or incomplete (non-CS, n\u2009=\u200958) success. Echocardiography was performed at baseline and at a median of 25 months post-SAAE. Left ventricular remodeling was evaluated using LVMI, predicted LVMI (pLVMI), and inappropriately excessive LVMI (ieLVMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SAAE significantly reduced both office and 24-h blood pressure in all patients (mean \u039424-h SBP: \u221219.3 mmHg; \u039424-h DBP: \u22129.8 mmHg; all P\u2009&amp;lt;\u2009.001). The CS group demonstrated greater improvement in plasma aldosterone concentration, aldosterone-to-renin ratio, and serum potassium (all P\u2009&amp;lt;\u2009.001). Both groups showed reductions in LVMI and pLVMI, but only the CS group had significant regression in ieLVMI (\u22125.77 vs +2.36 g\/m2; P\u2009=\u2009.010), indicating reversal of aldosterone-specific myocardial injury. This association remained significant after adjustment. Subgroup analyses showed consistent trends across age, sex, BMI, and adenoma status. Left ventricular hypertrophy prevalence declined from 31.8% to 17.1% overall (P\u2009&amp;lt;\u2009.001). Adverse events were mild and comparable between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In unilateral PA, sustained biochemical normalization after SAAE is associated with meaningful regression of aldosterone-mediated cardiac remodeling. These findings support SAAE may serve as a potential alternative for selected patients and highlight ieLVMI as a mechanistic treatment marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpag015","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:34:53Z","timestamp":1772195693000},"page":"1132-1141","source":"Crossref","is-referenced-by-count":1,"title":["Biochemical success after selective adrenal arterial embolization predicts long-term regression of aldosterone-mediated cardiac remodeling"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1534-9897","authenticated-orcid":false,"given":"Wen-Liang","family":"Shuai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University , 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Jiangxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University , Jiangxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Tian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University , Jiangxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-1491","authenticated-orcid":false,"given":"Yi-Fei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University , Jiangxi,","place":["China"]},{"name":"Molecular Medicine of Jiangxi Key Laboratory, 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