{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:07:56Z","timestamp":1789546076068,"version":"build-2803163510"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005632","name":"Forest Laboratories","doi-asserted-by":"publisher","award":["NCT05170061"],"award-info":[{"award-number":["NCT05170061"]}],"id":[{"id":"10.13039\/100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is little information about systemic hemodynamic changes in the evolution of heart failure (HF) from hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared 24-hour mean hemodynamic variables derived from ambulatory pulse wave analysis (Mobil-O-Graph) in at-risk patients with hypertension (Stage A\/B HF) and patients with Stage C HF secondarily stratified by ejection fraction (EF: low &amp;lt;40% or high \u226540%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Differences (mean \u00b1 SEM) between Stage A\/B (n\u2009=\u2009109) and Stage C HF (n\u2009=\u200952) were, respectively: stroke volume index (SVI) 36.8 vs. 31.9\u00a0mL\/m2 (P\u2009&amp;lt;\u2009.001), heart rate (HR) 68.1 vs. 76.4 bpm (P\u2009&amp;lt;\u2009.001), and arterial stiffness (pulse pressure\/SVI) 1.47 vs. 1.65\u00a0mmHg\/mL\/m2 (P\u2009&amp;lt;\u2009.05); cardiac index and total vascular resistance index did not differ between groups. Robust inverse correlations between SVI and HR were found in both Stage A\/B and Stage C HF (P\u2009&amp;lt;\u2009.001); each 10 beat\/min change in HR was accompanied by a reciprocal SVI change of 3\u00a0mL\/m2; overall, SVI was 5%-10% lower in Stage C compared to Stage A\/B HF. Hemodynamic profiles, especially high HR and low SVI, were quantitatively similar in Stage C HF patients with low or high EF. Low SVI (&amp;lt;35\u00a0mL\/min\/m2) conferred a specificity for Stage C HF of 71%; adding high HR (&amp;gt;75\u2009bpm) increased specificity to 84%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ambulatory hemodynamic monitoring is feasible in HF patients; low 24-hour SVI and high HR are highly correlated and together can differentiate Stage C from Stage A\/B HF, irrespective of EF. Further study of hemodynamic profiles in HF staging and prognosis is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpag067","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:19:57Z","timestamp":1783084797000},"page":"1222-1230","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic evolution of heart failure from hypertension: lower stroke volume index and higher heart rate"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-8370","authenticated-orcid":false,"given":"Joseph L","family":"Izzo","sequence":"first","affiliation":[{"name":"Department of Medicine, Jacobs School of Medicine, University at Buffalo , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambasiva R","family":"Srungavarapu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobs School of Medicine, University at Buffalo , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chander P","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobs School of Medicine, University at Buffalo , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fnu","family":"Shalini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobs School of Medicine, University at Buffalo , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Osmond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobs School of Medicine, University at Buffalo , Buffalo, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026091603515374400_hpag067-B1","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1161\/01.cir.0000039105.49749.6f","article-title":"Lifetime risk for developing congestive heart failure: the Framingham Heart Study","volume":"106","author":"Lloyd-Jones","year":"2002","journal-title":"Circulation"},{"key":"2026091603515374400_hpag067-B2","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1136\/hrt.2011.225482","article-title":"Systolic blood pressure and incident heart failure in the elderly. 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