{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:43:41Z","timestamp":1792568621897,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Orthostatic hypotension (OH) is common among older adults actively prescribed hypertension pharmacotherapy. Associations between antihypertensives and OH are inconsistent, due to differences in drug classes and OH assessment protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three supine and six standing blood pressures (BPs) were measured over 6\u2009minutes, timed to initiate immediately (0\u2009minutes) and 1, 2, 3, 4, and 5\u2009minutes after standing. OH was defined as a drop of systolic\/diastolic BP\u2009\u2265\u200920\/10\u2009mmHg upon standing from the supine position. OH phenotypes were initial (immediately after standing), early (within 3\u2009minutes), late (after 3\u2009minutes), and sustained (during 6\u2009minutes of standing). Participants were asked about orthostatic symptoms experienced during OH assessment. We investigated associations of antihypertensive classes with OH phenotypes and orthostatic symptoms via multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 863 participants (mean age 84 years), 41% had initial, 24% early, 18% late, and 17% sustained OH; 81% used antihypertensive medications. First-line antihypertensives (renin angiotensin aldosterone system blockers, dihydropyridine calcium channel blockers, and thiazide diuretics) were not associated with OH or orthostatic symptoms. Among non-first-line, alpha blockers were significantly associated with initial OH (OR 1.80, 95%CI 1.07, 3.01) and orthostatic symptoms during postural change (OR 2.64, 95%CI 1.34, 5.23), whereas combined alpha-beta blockers were significantly associated with early, late, or sustained OH (2.24 [1.15, 4.37], 2.50 [1.21, 5.17], 2.99 [1.41, 6.30], respectively) and experienced symptoms while standing (3.08 [1.10, 8.65]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>First-line antihypertensives are not associated with OH among older adults, which does not support their discontinuation in the setting of non-neurogenic OH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpag126","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:26:46Z","timestamp":1792567606000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of Antihypertensive Medications with Orthostatic Hypotension among OIder Adults"],"prefix":"10.1093","author":[{"given":"Md Marufuzzaman","family":"Khan","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Col","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick","family":"Larbi Kwapong","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhrumil","family":"Patil","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth-Alma N","family":"Turkson-Ocran","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H","family":"Ngo","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Cluett","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Mukamal","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Selvin","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L","family":"Lutsey","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Public Health, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Gwen","family":"Windham","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, The MIND Center , Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Mosley","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, The MIND Center , Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M","family":"Hughes","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine , Winston-Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis A","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"},{"name":"Hebrew SeniorLife Marcus Institute for Aging Research , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[{"name":"NYU Langone Health Grossman School of Medicine , NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Valint","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill , Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P","family":"Juraschek","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA"},{"name":"Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"container-title":["American Journal of 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