{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:40:11Z","timestamp":1774543211698,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>To examine possible associations between midregional proatrial natriuretic peptide (MR-proANP) and diabetic complications at baseline and risk of mortality and end-stage renal disease (ESRD) during follow-up in type 1 diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Observational study including 667 patients, with plasma MR-proANP measured at baseline. Complications were defined as micro- (n = 168) or macroalbuminuria (n = 190) (urinary albumin excretion rate (UAER) 30\u2013299 or \u2265300mg\/24h), previous cardiovascular disease (CVD) (n = 143), cardiac autonomic dysfunction (heart rate variability &amp;lt; 11 beats\/min) (n = 369), and retinopathy (n = 523). Adjustments included gender, age, systolic blood pressure, estimated glomerular filtration rate (eGFR), UAER, HbA1c, total cholesterol, 24-hour urinary sodium excretion (24h-UNa), body mass index, daily insulin dose, antihypertensive treatment, and smoking in linear regression analyses and analysis of covariance models. Development of ESRD (dialysis, renal transplantation, or GFR\/eGFR &amp;lt; 15ml\/min\/1.73 m2) and mortality was recorded through national registers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The cohort included 293 (44%) females, aged 55 \u00b1 13 years. Plasma MR-proANP (median (interquartile)) was 74.7 (49.2\u2013116.8) pmol\/L. Adjusted, MR-proANP correlated positively with age and UAER and negatively with eGFR, 24h-UNa, total cholesterol, and HbA1c (P &amp;lt; 0.05). Moreover, MR-proANP levels increased with albuminuria degree and were higher in patients with previous CVD (P \u2264 0.001), but similar in patients with or without autonomic dysfunction or retinopathy (P \u2265 0.076). During follow-up (3.5 (3.1\u20134.0) years), higher MR-proANP concentrations predicted ESRD and mortality combined (n = 35) adjusted for gender, age, systolic blood pressure, eGFR, and previous CVD (hazard ratio per 1SD increase in logANP: 2.8 (1.6\u20134.7; P &amp;lt; 0.001)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Increased plasma MR-proANP was associated with impaired renal function, increased albuminuria, and previous CVD. Moreover, MR-proANP concentrations were associated with increased risk of development of ESRD and mortality combined during follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpu227","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T04:51:32Z","timestamp":1417582292000},"page":"772-779","source":"Crossref","is-referenced-by-count":13,"title":["Increased Plasma Concentrations of Midregional Proatrial Natriuretic Peptide Is Associated With Risk of Cardiorenal Dysfunction in Type 1 Diabetes"],"prefix":"10.1093","volume":"28","author":[{"given":"Simone","family":"Theilade","sequence":"first","affiliation":[{"name":"Steno Diabetes Center 1 , Gentofte , Denmark ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine Willum","family":"Hansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center 1 , Gentofte , Denmark ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens 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