{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:25:22Z","timestamp":1764084322032},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Combination treatments for hypertension most often include a renin\u2013angiotensin\u2013aldosterone system (RAAS) inhibitor. However, systolic blood pressure (SBP) remains difficult to control. Non-RAAS-inhibiting strategies such as calcium channel blocker\/thiazide-like diuretic combinations may offer effective alternatives.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Hypertensive diabetic patients with microalbuminuria were included in this retrospective, post-hoc analysis of the Natrilix SR Versus Enalapril Study in Hypertensive Type 2 Diabetics With MicrOalbuminuRia (NESTOR) trial if they were uncontrolled on monotherapy (indapamide slow release (SR) 1.5mg or enalapril 10mg) and had been given add-on amlodipine 5mg. Patients uncontrolled with monotherapy\/amlodipine 5mg were uptitrated to 10mg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After 52 weeks, supine SBP\/diastolic BP (DBP) decreased from baseline by 26\u00b113\/14\u00b19mm Hg in the indapamide SR\/amlodipine group (n = 135) and by 21\u00b114\/11\u00b19mm Hg in the enalapril\/amlodipine group (n = 156) (P = 0.006 for \u0394SBP). In the amlodipine 10mg subgroup, SBP\/DBP decreased from baseline by 26\u00b113\/13\u00b19mm Hg in the indapamide SR\/amlodipine group (n = 62) and by 20\u00b113\/12\u00b18mm Hg in the enalapril\/amlodipine group (n = 77) (P = 0.02 for \u0394SBP). Treatment with indapamide SR\/amlodipine was well tolerated. Few patients experienced edema, with no between-group differences. As expected with diuretics, slight changes in kalemia and in uricemia were observed in the indapamide SR\/amlodipine group. Changes in fasting glucose, lipids, natremia, and creatinine clearance were similar between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Indapamide SR\/amlodipine results in superior SBP reduction with a safety profile in line with that of its components and tolerability equivalent to that of an angiotensin-converting enzyme inhibitor\/amlodipine strategy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpu297","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T02:43:59Z","timestamp":1422413039000},"page":"1064-1071","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of Hypertensive Patients With Diabetes and Microalbuminuria With Combination Indapamide SR\/Amlodipine: Retrospective Analysis of NESTOR"],"prefix":"10.1093","volume":"28","author":[{"given":"Olivier","family":"Hanon","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4468 1 , Paris , France ;"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Broca, Service de G\u00e9riatrie 2 , Paris , France ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemence","family":"Boully","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4468 1 , Paris , France ;"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Broca, Service de G\u00e9riatrie 2 , Paris , France ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Caillard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4468 1 , Paris , France ;"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Broca, Service de G\u00e9riatrie 2 , Paris , France ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Labour\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4468 1 , Paris , France ;"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Broca, Service de G\u00e9riatrie 2 , Paris , France ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Cochiello","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4468 1 , Paris , France ;"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Broca, Service de G\u00e9riatrie 2 , Paris , France ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Chaussade","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4468 1 , 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