{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:34:51Z","timestamp":1760549691595},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>We aimed to evaluate a possible association between serum uric acid (SUA) levels and carotid-to-femoral pulse wave velocity (cf-PWV) among healthy participants of the ELSA-Brasil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We excluded subjects using antihypertensive medication, diuretics, allopurinol, binge drinkers, body mass index (BMI) &amp;gt;35kg\/m2, and those with history of cardiovascular diseases (CVD). In a cross-sectional and sex-specific analysis, linear regression models were built having cf-PWV as dependent variable and SUA as independent variable. Multiple adjustments were subsequently made for age, heart rate and blood pressure, BMI, and fasting glucose levels as covariates. Product interaction terms were built to test interaction between SUA and other covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We analyzed 1,875 men and 1,713 women (mean ages, 48.9\u00b18.4 and 50.2\u00b18.7 years, respectively). SUA was linearly associated with cf-PWV in men (P = 0.01) and in women (P = 0.01). After full adjustment, the association remained significant for men (P = 0.01) and no longer significant for women (P = 0.10). Fully adjusted linear coefficients \u03b2 (95% CI) were 0.06 (0.015; 0.112) and 0.04 (\u22120.01; 0.12) in men and women, respectively. Significant interaction between SUA and age (P = 0.02) fasting glucose (P &amp;lt; 0.01) and BMI (P = 0.02) was found only for women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>In an apparently healthy population, SUA was significantly associated to cf-PWV in men but not in women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpu298","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T04:46:22Z","timestamp":1421901982000},"page":"966-970","source":"Crossref","is-referenced-by-count":29,"title":["Serum Uric Acid and Pulse Wave Velocity Among Healthy Adults: Baseline Data From the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)"],"prefix":"10.1093","volume":"28","author":[{"given":"Cristina Pellegrino","family":"Baena","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 1 , Curitiba , Brazil ;"},{"name":"Centro de Pesquisa Cl\u00ednica e Epidemiol\u00f3gica 2 , , , S\u00e3o Paulo , Brazil ;"},{"name":"Hospital Universit\u00e1rio 2 , , , S\u00e3o Paulo , Brazil ;"},{"name":"Universidade de S\u00e3o Paulo 2 , , , S\u00e3o Paulo , Brazil ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Andrade","family":"Lotufo","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa Cl\u00ednica e Epidemiol\u00f3gica 2 , , , S\u00e3o Paulo , Brazil ;"},{"name":"Hospital Universit\u00e1rio 2 , , , S\u00e3o Paulo , Brazil ;"},{"name":"Universidade de S\u00e3o Paulo 2 , , , S\u00e3o Paulo , Brazil ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Geraldo","family":"Mill","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo 3 , Esp\u00edrito Santo , Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto de Sa","family":"Cunha","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo 3 , Esp\u00edrito Santo , Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela J","family":"Bense\u00f1or","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa Cl\u00ednica e Epidemiol\u00f3gica 2 , , , S\u00e3o Paulo , Brazil ;"},{"name":"Hospital Universit\u00e1rio 2 , , , S\u00e3o Paulo , Brazil ;"},{"name":"Universidade de S\u00e3o Paulo 2 , , , S\u00e3o Paulo , Brazil ;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"key":"2024020714493295700_CIT0001","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0140-6736(02)45936-3","article-title":"On chronic Bright\u2019s disease, and its essential symptoms","volume":"113","author":"Mahomed","year":"1879","journal-title":"The 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