{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:44:33Z","timestamp":1743745473795},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>This study analyzed the effects of chronic administration of N[omega]-hydroxy-nor-l-arginine (nor-NOHA), an inhibitor of arginase, on the hemodynamic, oxidative stress, morphologic, metabolic, and renal manifestations of hyperthyroidism in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Four groups of male Wistar rats were used: control, nor-NOHA-treated (10mg\/kg\/day), thyroxine (T4)-treated (75 \u03bcg\/rat\/day), and thyroxine- plus nor-NOHA-treated rats. All treatments were maintained for 4 weeks. Body weight, tail systolic blood pressure (SBP), and heart rate (HR) were recorded weekly. Finally, morphologic, metabolic, plasma, and renal variables were measured. Arginase I and II protein abundance and arginase activity were measured in aorta, heart, and kidney.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The T4 group showed increased arginase I and II protein abundance, arginase activity, SBP, HR, plasma nitrates\/nitrites (NOx), brainstem and urinary isoprostanes, proteinuria and cardiac and renal hypertrophy in comparison to control rats. In hyperthyroid rats, chronic nor-NOHA prevented the increase in SBP and HR and decreased proteinuria in association with an increase in plasma NOx and a decrease in brainstem and urinary isoprostanes. In normal rats, nor-NOHA treatment did not significantly change any hemodynamic, morphologic, or renal variables. Acute nor-NOHA administration did not affect renal or systemic hemodynamic variables in normal or T4-treated rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Hyperthyroidism in rats is associated with the increased expression and activity of arginase in aorta, heart, and kidney. Chronic arginase inhibition with nor-NOHA suppresses the characteristic hemodynamic manifestations of hyperthyroidism in association with a reduced oxidative stress. These results indicate an important role for arginase pathway alterations in the cardiovascular and renal abnormalities of hyperthyroidism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpv049","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T01:32:22Z","timestamp":1429839142000},"page":"1464-1472","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats"],"prefix":"10.1093","volume":"28","author":[{"given":"Isabel","family":"Rodr\u00edguez-G\u00f3mez","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina 2 , Granada , Spain ;"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. Universidad de Granada 1 , Granada , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Manuel Moreno","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. Universidad de Granada 1 , Granada , Spain ;"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina 3 , Murcia , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. Universidad de Granada 1 , Granada , Spain ;"},{"name":"Departamento de Farmacolog\u00eda, Facultad de Farmacia 4 , Granada , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Quesada","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. Universidad de Granada 1 , Granada , Spain ;"},{"name":"Departamento de Ciencias de la Salud, Universidad de Ja\u00e9n 5 , Ja\u00e9n , Spain ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Montoro-Molina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. Universidad de Granada 1 , Granada , Spain ;"},{"name":"Departamento de Ciencias de la Salud, Universidad de Ja\u00e9n 5 , Ja\u00e9n , Spain ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Vargas-Tendero","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina 2 , Granada , Spain ;"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. Universidad de Granada 1 , Granada , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Wangensteen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada. 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