{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:35:12Z","timestamp":1759336512892},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Recent studies have shown that arterial stiffness is reduced after meal intake. We evaluated the acute response of central hemodynamics to glucose loading and the variation in their responses among normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and diabetes mellitus (DM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The study enrolled 85 patients with known or suspected coronary artery disease who underwent a 75-g oral glucose tolerance test. Central hemodynamic measurements were assessed using radial applanation tonometry at fasting, 60, and 120 minutes after glucose loading.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Glucose loading decreased the augmentation index normalized to a heart rate of 75 bpm (AIx@75) (81.6\u00b113.9 to 74.5\u00b114.1%, P &amp;lt; 0.01) and central systolic blood pressure (SBP) (115\u00b122 to 109\u00b121mm Hg, P &amp;lt; 0.01) at 120 minutes without a significant change in brachial SBP (126\u00b125 to 125\u00b125mm Hg, P = 0.93). Glucose loading decreased central SBP in NGT and IGT groups but did not affect the DM group. Change in AIx@75 at 120 minutes after glucose loading was blunted in IGT and DM groups compared with the NGT group (\u22125.7\u00b14.4 vs. \u22123.6\u00b14.1 vs. \u22129.3\u00b16.2%, P &amp;lt; 0.01). Multivariate logistic regression analysis identified DM as an independent factor associated with the presence of blunted response of AIx to glucose loading.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Oral glucose loading decreased central SBP and AIx@75 without a significant change in brachial SBP, and these central hemodynamic responses were blunted in patients with DM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpv120","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T23:59:50Z","timestamp":1437782390000},"page":"357-364","source":"Crossref","is-referenced-by-count":7,"title":["Reduction of Central Blood Pressure in Response to Oral Glucose\n                    Loading Is Blunted in Patients With Diabetes Mellitus"],"prefix":"10.1093","volume":"29","author":[{"given":"Tadanao","family":"Higaki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kurisu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ikenaga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shimonaga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuki","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences 1 , Hiroshima , Japan ."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"2024012721425666000_CIT0001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/08037059409101519","article-title":"Arterial haemodynamics and ventricular-vascular\n                        interaction in hypertension","volume":"3","author":"O\u2019Rourke","year":"1994","journal-title":"Blood Press"},{"key":"2024012721425666000_CIT0002","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/HYPERTENSIONAHA.107.090068","article-title":"Central blood pressure measurements and\n                        antihypertensive therapy: a consensus document","volume":"50","author":"Agabiti-Rosei","year":"2007","journal-title":"Hypertension"},{"key":"2024012721425666000_CIT0003","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00001573-200209000-00016","article-title":"Augmentation index as a measure of peripheral\n                        vascular disease state","volume":"17","author":"Nichols","year":"2002","journal-title":"Curr Opin Cardiol"},{"key":"2024012721425666000_CIT0004","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1291\/hypres.30.219","article-title":"Relationship between radial and central arterial\n                        pulse wave and evaluation of central aortic pressure using the radial\n                        arterial pulse wave","volume":"30","author":"Takazawa","year":"2007","journal-title":"Hypertens Res"},{"key":"2024012721425666000_CIT0005","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/ajh.2011.145","article-title":"Validation of the noninvasive assessment of\n                        central blood pressure by the SphygmoCor and Omron devices against the\n                        invasive catheter measurement","volume":"24","author":"Ding","year":"2011","journal-title":"Am J\n                        Hypertens"},{"key":"2024012721425666000_CIT0006","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/HJH.0b013e32835a8eca","article-title":"Comparison of the SphygmoCor and Omron devices\n                        in the estimation of pressure amplification against the invasive catheter\n                        measurement","volume":"31","author":"Ding","year":"2013","journal-title":"J Hypertens"},{"key":"2024012721425666000_CIT0007","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/HJH.0b013e3283524910","article-title":"Estimation of central aortic systolic pressure\n                        using late systolic inflection of radial artery pulse and its application to\n                        vasodilator therapy","volume":"30","author":"Takazawa","year":"2012","journal-title":"J Hypertens"},{"key":"2024012721425666000_CIT0008","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1097\/HJH.0b013e32832e0b58","article-title":"The accuracy of central SBP\n                        determined from the second systolic peak of the peripheral pressure\n                        waveform","volume":"27","author":"Hickson","year":"2009","journal-title":"J Hypertens"},{"key":"2024012721425666000_CIT0009","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/HYPERTENSIONAHA.107.096016","article-title":"Peripheral augmentation index defines the\n                        relationship between central and peripheral pulse pressure","volume":"51","author":"Munir","year":"2008","journal-title":"Hypertension"},{"key":"2024012721425666000_CIT0010","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3945\/ajcn.2009.27771","article-title":"Acute effects of food on postprandial blood\n                        pressure and measures of arterial stiffness in healthy\n                        humans","volume":"90","author":"Ahuja","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"2024012721425666000_CIT0011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1475-2891-12-93","article-title":"Postprandial effect of dietary fat quantity and\n                        quality on arterial stiffness and wave reflection: a randomised controlled\n                        trial","volume":"12","author":"Lithander","year":"2013","journal-title":"Nutr J"},{"key":"2024012721425666000_CIT0012","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/ajh\/hpt211","article-title":"Acute effects of a mixed meal on arterial\n                        stiffness and central hemodynamics in healthy adults","volume":"27","author":"Taylor","year":"2014","journal-title":"Am J Hypertens"},{"key":"2024012721425666000_CIT0013","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.atherosclerosis.2009.11.003","article-title":"Dysfunctional central hemodynamic regulation\n                        after daily meal intake in metabolic syndrome","volume":"210","author":"Funada","year":"2010","journal-title":"Atherosclerosis"},{"key":"2024012721425666000_CIT0014","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s001250051107","article-title":"The relative risks of hyperglycaemia, obesity\n                        and dyslipidaemia in the relatives of patients with Type II diabetes\n                        mellitus","volume":"42","author":"Shaw","year":"1999","journal-title":"Diabetologia"},{"key":"2024012721425666000_CIT0015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archinte.161.3.397","article-title":"Glucose tolerance and cardiovascular mortality: comparison of\n                        fasting and 2-hour diagnostic criteria","volume":"161","year":"2001","journal-title":"Arch Intern\n                        Med"},{"key":"2024012721425666000_CIT0016","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2337\/diacare.22.6.920","article-title":"Impaired glucose tolerance is a risk factor for\n                        cardiovascular disease, but not impaired fasting glucose. The Funagata\n                        Diabetes Study","volume":"22","author":"Tominaga","year":"1999","journal-title":"Diabetes Care"},{"key":"2024012721425666000_CIT0017","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.atherosclerosis.2013.07.054","article-title":"Central hemodynamic modifications in diabetes\n                        mellitus","volume":"230","author":"Agnoletti","year":"2013","journal-title":"Atherosclerosis"},{"key":"2024012721425666000_CIT0018","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.2337\/dc12-s004","article-title":"Executive\n                        summary: standards of medical care in diabetes--2012","volume":"35","author":"American Diabetes Association","year":"2012","journal-title":"Diabetes Care"},{"key":"2024012721425666000_CIT0019","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1056-8727(98)00019-1","article-title":"Hyperglycemia without hyperinsulinemia produces\n                        both sympathetic neural activation and vasodilation in normal\n                        humans","volume":"13","author":"Hoffman","year":"1999","journal-title":"J Diabetes Complications"},{"key":"2024012721425666000_CIT0020","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1007\/s00125-007-0730-0","article-title":"Acute hyperglycaemia rapidly increases arterial\n                        stiffness in young patients with type 1 diabetes","volume":"50","author":"Gordin","year":"2007","journal-title":"Diabetologia"},{"key":"2024012721425666000_CIT0021","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/01.HYP.33.5.1118","article-title":"Diminished wave reflection in the aorta. A novel\n                        physiological action of insulin on large blood vessels","volume":"33","author":"Westerbacka","year":"1999","journal-title":"Hypertension"},{"key":"2024012721425666000_CIT0022","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.2337\/diacare.25.12.2314","article-title":"Insulin-induced decreases in aortic wave\n                        reflection and central systolic pressure are impaired in type 2\n                        diabetes","volume":"25","author":"Tamminen","year":"2002","journal-title":"Diabetes Care"},{"key":"2024012721425666000_CIT0023","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1172\/JCI117433","article-title":"Insulin-mediated skeletal muscle vasodilation is\n                        nitric oxide dependent. A novel action of insulin to increase nitric oxide\n                        release","volume":"94","author":"Steinberg","year":"1994","journal-title":"J Clin Invest"},{"key":"2024012721425666000_CIT0024","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJM199201023260104","article-title":"Role of reduced suppression of glucose\n                        production and diminished early insulin release in impaired glucose\n                        tolerance","volume":"326","author":"Mitrakou","year":"1992","journal-title":"N Engl J Med"},{"key":"2024012721425666000_CIT0025","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1001\/archinte.163.11.1306","article-title":"Clinical significance, pathogenesis, and\n                        management of postprandial hyperglycemia","volume":"163","author":"Gerich","year":"2003","journal-title":"Arch\n                        Intern Med"},{"key":"2024012721425666000_CIT0026","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0735-1097(99)00168-0","article-title":"Hyperglycemia rapidly suppresses flow-mediated\n                        endothelium-dependent vasodilation of brachial artery","volume":"34","author":"Kawano","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"2024012721425666000_CIT0027","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.amjcard.2008.03.087","article-title":"Endothelial dysfunction in impaired fasting\n                        glycemia, impaired glucose tolerance, and type 2 diabetes\n                        mellitus","volume":"102","author":"Su","year":"2008","journal-title":"Am J Cardiol"},{"key":"2024012721425666000_CIT0028","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.105.595496","article-title":"Differential impact of blood pressure-lowering drugs on\n                        central aortic pressure and clinical outcomes: principal results of the\n                        Conduit Artery Function Evaluation (CAFE) study","volume":"113","author":"Williams","year":"2006","journal-title":"Circulation"},{"key":"2024012721425666000_CIT0029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/HYPERTENSIONAHA.107.089078","article-title":"Central pressure more strongly relates to\n                        vascular disease and outcome than does brachial pressure: the Strong Heart\n                        Study","volume":"50","author":"Roman","year":"2007","journal-title":"Hypertension"},{"key":"2024012721425666000_CIT0030","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.jacc.2009.05.070","article-title":"High central pulse pressure is independently\n                        associated with adverse cardiovascular outcome the strong heart\n                        study","volume":"54","author":"Roman","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2024012721425666000_CIT0031","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/HJH.0b013e3283501354","article-title":"Estimation of central aortic systolic pressure\n                        from the second systolic peak of the peripheral upper limb pulse depends on\n                        central aortic pressure waveform morphology","volume":"30","author":"Lin","year":"2012","journal-title":"J\n                        Hypertens"},{"key":"2024012721425666000_CIT0032","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.HYP.0000057574.64076.A5","article-title":"Pressure wave reflection assessed from the\n                        peripheral pulse: is a transfer function necessary?","volume":"41","author":"Millasseau","year":"2003","journal-title":"Hypertension"},{"key":"2024012721425666000_CIT0033","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/bja\/aeh121","article-title":"The second peak of the radial artery pressure\n                        wave represents aortic systolic pressure in hypertensive and elderly\n                        patients","volume":"92","author":"Pauca","year":"2004","journal-title":"Br J Anaesth"},{"key":"2024012721425666000_CIT0034","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/HJH.0b013e328346a3bc","article-title":"Comparison of central pressure estimates\n                        obtained from SphygmoCor, Omron HEM-9000AI and carotid applanation\n                        tonometry","volume":"29","author":"Kips","year":"2011","journal-title":"J Hypertens"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/article\/29\/3\/357\/2283853","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article\/29\/3\/357\/2283853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T21:43:41Z","timestamp":1706391821000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/29\/3\/357\/2283853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,7,23]]},"published-print":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpv120","relation":{},"ISSN":["1941-7225","0895-7061"],"issn-type":[{"value":"1941-7225","type":"electronic"},{"value":"0895-7061","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,3]]},"published":{"date-parts":[[2015,7,23]]}}}