{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:30Z","timestamp":1791300510433,"version":"4.1.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>New evidence suggests that central systolic blood pressure (cSBP) and augmentation index (AI) are superior predictors of adverse cardiovascular outcomes compared to peripheral systolic BP (pSBP). We performed a meta-analysis assessing the impact of antihypertensives on cSBP and AI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>PubMed, Cochrane Library, and CINAHL were searched until September 2014 to identify eligible articles. A DerSimonian and Laird random-effects model was used to calculate the weighted mean difference (WMD) and its 95% confidence interval (CI). Fifty-two and 58 studies incorporating 4,381 and 3,716 unique subjects were included for cSBP and AI analysis, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Overall, antihypertensives reduced pSBP more than cSBP (WMD 2.52mm Hg, 95% CI 1.35 to 3.69; I2 = 21.9%). \u03b2-Blockers (BBs) posed a significantly greater reduction in pSBP as compared to cSBP (WMD 5.19mm Hg, 95% CI 3.21 to 7.18). \u03b1-Blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, diuretics, renin-angiotensin aldosterone system inhibitors and nicorandil reduced cSBP and pSBP in a similar manner. The overall reduction in AI from baseline was 3.09% (95% CI 2.28 to 3.90; I2 = 84.5%). A significant reduction in AI was seen with angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, diuretics, renin-angiotensin aldosterone system inhibitors, BBs, \u03b1-blockers (ABs), nicorandil, and moxonidine reduced AI nonsignificantly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>BBs are not as beneficial as the other antihypertensives in reducing cSBP and AI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpv134","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T01:10:20Z","timestamp":1440033020000},"page":"448-457","source":"Crossref","is-referenced-by-count":40,"title":["Impact of Antihypertensive Agents on Central Systolic Blood Pressure and Augmentation Index: A Meta-Analysis"],"prefix":"10.1093","volume":"29","author":[{"given":"Tracey J.","family":"McGaughey","sequence":"first","affiliation":[{"name":"Department of Pharmacy, David Grant Medical Center, Travis Air Force Base Fairfield, California, USA 1 ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, David Grant Medical Center, Travis Air Force Base Fairfield, California, USA 1 ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, David Grant Medical Center, Travis Air Force Base Fairfield, California, USA 1 ;"},{"name":"Department of Pharmacy Practice, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific 2 , Stockton, California , USA 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