{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:04:13Z","timestamp":1782345853573,"version":"3.54.5"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Hyperandrogenemia in females may be associated with sympathetic nervous system (SNS) activation and increased blood pressure (BP). However the importance of hyperandrogenemia in causing hypertension in females and the mechanisms involved are still unclear. We tested whether chronic hyperandrogenemia exacerbates hypertension in young female spontaneously hypertensive rats (SHR) and whether endogenous melanocortin-3\/4 receptor (MC3\/4R) activation contributes to the elevated BP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Cardiovascular and metabolic effects of chronic MC3\/4R antagonism were assessed in female SHR treated with dihydrotestosterone (DHT, beginning at 5 weeks of age) and placebo-treated female SHR. BP and heart rate (HR) were measured by telemetry and an intracerebroventricular (ICV) cannula was placed in the lateral ventricle for infusions. After control measurements, the MC3\/4R antagonist (SHU-9119) was infused for 10 days (1 nmol\/hour, ICV, at 15 weeks of age) followed by a 5-day recovery period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>MC3\/4R antagonism increased food intake and body weight in DHT-treated SHR (14\u00b11 to 35\u00b11g\/day and 244\u00b13 to 298\u00b18g) and controls (14\u00b11 to 34\u00b12g\/day and 207\u00b14 to 269\u00b18g). Compared to untreated SHR, DHT-treated SHR had similar BP but lower HR (146\u00b13 vs. 142\u00b14mm Hg and 316\u00b12 vs. 363\u00b14 bpm). Chronic SHU-9119 infusion reduced BP and HR in DHT-treated SHR (\u221212\u00b12mm Hg and \u221214\u00b14 bpm) and control female SHR (\u221219\u00b12mm Hg and \u221221\u00b16 bpm).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>These results indicate that hyperandrogenemia does not exacerbate hypertension in female SHR. MC3\/4R antagonism reduces BP and HR despite marked increases in food intake and body weight in hyperandrogenemic and control female SHR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpv182","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T21:13:14Z","timestamp":1452546794000},"page":"832-840","source":"Crossref","is-referenced-by-count":2,"title":["Regulation of Blood Pressure, Appetite, and Glucose by CNS Melanocortin System in Hyperandrogenemic Female SHR"],"prefix":"10.1093","volume":"29","author":[{"given":"Jussara M.","family":"do Carmo","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center 1 , Jackson, Mississippi , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre A.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center 1 , Jackson, Mississippi , USA ;"},{"name":"Bar\u00e3o de Mau\u00e1 University Center 2 , Ribeir\u00e3o Preto, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney P.","family":"Moak","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center 1 , Jackson, Mississippi , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley J.","family":"Houghton","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center 1 , Jackson, Mississippi , USA 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