{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:11:09Z","timestamp":1761581469109},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Sympathetic renal denervation (SRD) has been proposed as a therapeutic alternative for patients with resistant hypertension not controlled on pharmacological therapy. Two studies have suggested an effect of SRD in reducing short-term blood pressure variability (BPV). However, this has not been addressed in a randomized comparative trial. We aimed to compare the effects of spironolactone and SRD on circadian BP and BPV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This is a post-hoc analysis of a randomized trial in 24 true resistant hypertensive patients (15 men, 9 women; mean age 64 years) comparing 50mg of spironolactone (n = 13) vs. SRD (n = 11) on 24-hour BP. We report here the comparative effects on daytime (8 am\u201310 pm) and nighttime (0 am\u20136 am) BP, night-to-day ratios and BP and heart rate variabilities (SD and coefficient of variation of 24-hour, day and night, as well as weighted SD and average real variability (ARV)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Spironolactone was more effective than SRD in reducing daytime systolic (P = 0.006), daytime diastolic (P = 0.006), and nighttime systolic (P = 0.050) BP. No differences were observed in the night-to-day ratios. In contrast, SRD-reduced diastolic BPV (24 hours, daytime, nighttime, weighted, and ARV; all P &amp;lt; 0.05) with respect to spironolactone, without significant differences in systolic BPV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Spironolactone is more effective than SRD in reducing ambulatory BP. However, BPV is significantly more reduced with SRD. This effect could be important in terms of potential prevention beyond BP reduction and deserves further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpw085","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T02:29:11Z","timestamp":1474424951000},"page":"37-41","source":"Crossref","is-referenced-by-count":17,"title":["Renal Denervation vs. Spironolactone in Resistant Hypertension: Effects on Circadian Patterns and Blood Pressure Variability"],"prefix":"10.1093","volume":"30","author":[{"given":"Alejandro","family":"de la Sierra","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona 1 , Barcelona , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Pareja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital de l\u2019Esperit Sant 2 , Santa Coloma de Gramenet , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Armario","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Mois\u00e9s Broggi 3 , Sant Joan Desp\u00ed , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Barrera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona 1 , Barcelona , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona 1 , Barcelona , Spain ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar 4 , Barcelona , Spain ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Sans","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar 4 , Barcelona , Spain ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar 4 , Barcelona , Spain ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Oliveras","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar 4 , Barcelona , Spain ."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"2024020715443891800_CIT0001","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrcardio.2013.1","article-title":"Assessment and management of blood-pressure 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antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial","volume":"385","author":"Azizi","year":"2015","journal-title":"Lancet"},{"key":"2024020715443891800_CIT0010","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","article-title":"A controlled trial of renal denervation for resistant hypertension","volume":"370","author":"Bhatt","year":"2014","journal-title":"N Engl J Med"},{"key":"2024020715443891800_CIT0011","article-title":"Spironolactone versus sympathetic renal denervation to treat true resistant hypertension: results from the DENERVHTA study\u2014a randomized controlled trial","author":"Oliveras","year":"2016","journal-title":"J Hypertens"},{"key":"2024020715443891800_CIT0012","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cjca.2014.12.004","article-title":"Renal denervation after SYMPLICITY HTN-3: where do we 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