{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T23:02:46Z","timestamp":1754262166935,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institutes of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","award":["IIS-175"],"award-info":[{"award-number":["IIS-175"]}],"id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["12GRNT12060613","14POST20450173"],"award-info":[{"award-number":["12GRNT12060613","14POST20450173"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Radiofrequency ablation of the renal arteries (RF-ABL) has been shown to decrease blood pressure (BP) in drug-resistant hypertensive patients who receive antihypertensive drug therapy. However, there remain questions regarding how RF-ABL influences BP independent of drug therapy and whether complete renal denervation is necessary to maximally lower BP. To study these questions, we examined the cardiovascular, sympathetic, and renal effects produced by RF-ABL of the proximal renal arteries in spontaneously hypertensive rats (SHR) with established hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>SHR were instrumented (telemetry) for measurement of systolic\/diastolic BP (SBP\/DBP). Rats then underwent Sham-ABL or RF-ABL adjacent to the renal ostium and BP was recorded for 8 weeks. Changes in sympathetic activity, 24-hour water\/sodium excretion, and levels of urinary angiotensinogen (AGT), plasma renin activity, and kidney renin content (KRC) were measured in SHR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Compared with Sham-ABL, RF-ABL produced a sustained decrease in BP. At 8 weeks, SBP\/DBP was 171\u00b16\/115\u00b13 and 183\u00b14\/129\u00b13mm Hg for RF-ABL and Sham-ABL SHR, respectively. Correlating with the reduction in BP, RF-ABL significantly decreased the low frequency\/total and low frequency\/high frequency of BP variability and attenuated the hypotensive response to chlorisondamine. Kidney norepinephrine levels were markedly decreased at 8 weeks in RF-ABL vs. Sham-ABL SHR. There were no group differences in 24-hour sodium\/water excretion or urinary AGT excretion rate (6 weeks) or plasma renin activity or KRC (8 weeks). In other studies, concurrent RF-ABL plus surgical denervation initially decreased BP to a greater level than RF-ABL alone, but thereafter the reduction in BP between groups was not different.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In hypertensive SHR, bilateral RF-ABL of the proximal renal arteries produced a sustained decease in sympathetic activity and BP without changes in sodium\/water excretion or activity of the systemic\/renal renin\u2013angiotensin system.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpw089","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T02:29:14Z","timestamp":1471573754000},"page":"1394-1401","source":"Crossref","is-referenced-by-count":16,"title":["Sympathoinhibitory Effect of Radiofrequency Renal Denervation in Spontaneously Hypertensive Rats With Established Hypertension"],"prefix":"10.1093","volume":"29","author":[{"given":"Juan","family":"Gao","sequence":"first","affiliation":[{"name":"The Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center 1 , New Orleans, Louisiana , USA ;"},{"name":"The Cardiovascular Center of Excellence 2 , , New Orleans, Louisiana , USA ;"},{"name":"Louisiana State University Health Sciences Center 2 , , New Orleans, Louisiana , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund K.","family":"Kerut","sequence":"additional","affiliation":[{"name":"The Heart Clinic of Louisiana 3 , Marrero, Louisiana , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Smart","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center of Excellence 2 , , New Orleans, Louisiana , USA ;"},{"name":"Louisiana State University Health Sciences Center 2 , , New Orleans, Louisiana , USA ;"},{"name":"Department of Cardiology 4 , , New Orleans, Louisiana , USA ;"},{"name":"Louisiana State University Health Sciences Center 4 , , New Orleans, Louisiana , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Katsurada","sequence":"additional","affiliation":[{"name":"The Department of Physiology and the Hypertension and Renal Center of Excellence 5 , , New Orleans, Louisiana , USA ;"},{"name":"Tulane Health Sciences Center 5 , , New Orleans, Louisiana , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Seth","sequence":"additional","affiliation":[{"name":"The Department of Physiology and the Hypertension and Renal Center of Excellence 5 , , New Orleans, Louisiana , USA ;"},{"name":"Tulane Health Sciences Center 5 , , New Orleans, Louisiana , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Gabriel","family":"Navar","sequence":"additional","affiliation":[{"name":"The Department of Physiology and the Hypertension and Renal Center of Excellence 5 , , New Orleans, Louisiana , USA ;"},{"name":"Tulane Health Sciences Center 5 , , New Orleans, Louisiana , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Kapusta","sequence":"additional","affiliation":[{"name":"The Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center 1 , New Orleans, Louisiana , USA ;"},{"name":"The Cardiovascular Center of Excellence 2 , , New Orleans, Louisiana , USA ;"},{"name":"Louisiana State University Health Sciences Center 2 , , New Orleans, Louisiana , USA ;"},{"name":"Department of Anesthesiology 6 , , New Orleans, Louisiana , USA ."},{"name":"Louisiana State University Health Sciences Center 6 , , New Orleans, Louisiana , USA 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