{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:36:45Z","timestamp":1773297405866,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>The impact of metabolic phenotypes on the association of uricemia with urinary albumin\/creatinine ratio (uACR) remains unresolved. We evaluated the association between serum uric acid and uACR in persons with 0, and 1\u20132 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Using data from a cross-sectional survey of a representative Czech population aged 25\u201364 years (n = 3612), we analyzed 1,832 persons without decreased glomerular filtration rate &amp;lt;60ml\/min\/1.73 m2, diabetes, and MetS. MetS components were defined using the joint statement of the leading societies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 1,832 selected participants, 64.1% (n = 1174) presented with 1\u20132 MetS components (age 46.3\u00b111.2; men 51.7%), whereas 35.9% (n = 658) were free of any component (age 39.4\u00b110.0; men 34.2 %). In fully adjusted multiple linear regression models for uricemia, uACR was an independent factor for increase in uric acid levels only in persons with 1\u20132 MetS components (standardized beta (S\u03b2) 0.048; P = 0.024); however, not in those without any component (S\u03b2 0.030; P = 0.264). Uric acid levels increased by the interaction of uACR with VAI (S\u03b2 0.06; P = 0.012), and of uACR with MAP (S\u03b2 0.05; P = 0.009). Finally, the association of uACR with uricemia was confined to persons whose VAI together with MAP were \u2265the median of 1.35 and 98mm Hg, respectively (S\u03b2 0.190; P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>We demonstrated a strong modification effect of VAI and MAP on the association between uACR and uricemia, which suggests obesity-related hypertension as the underlying mechanism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpw098","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T03:18:53Z","timestamp":1472267933000},"page":"1335-1342","source":"Crossref","is-referenced-by-count":15,"title":["The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome"],"prefix":"10.1093","volume":"29","author":[{"given":"Alena","family":"Krajcoviechova","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital 1 , Prague , Czech Republic ;"},{"name":"Montreal University Hospital Research Center 2 , CHUM, Montr\u00e9al , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Montreal University Hospital Research Center 2 , CHUM, Montr\u00e9al , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital 1 , Prague , Czech Republic ;"},{"name":"Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine 3 , Prague , Czech Republic ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bruthans","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital 1 , Prague , Czech Republic ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhmmad Ramzan","family":"Tahir","sequence":"additional","affiliation":[{"name":"Montreal University Hospital Research Center 2 , CHUM, Montr\u00e9al , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Hamet","sequence":"additional","affiliation":[{"name":"Montreal University Hospital Research Center 2 , CHUM, Montr\u00e9al , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Cifkova","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital 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