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However, few studies have examined the impact of chronic stress on endothelial dysfunction. The purpose of this study was to examine whether chronic stress was associated with flow-mediated dilation (FMD) and 2 biomarkers of endothelial dysfunction (intercellular adhesion molecule-1 (ICAM-1) and E-selectin) in a multiethnic sample of adults (ages 45\u201384 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Data come from the baseline examination of Multi-Ethnic Study of Atherosclerosis participants. Chronic stress was assessed based on self-report of the presence and severity of ongoing problems in 5 domains. FMD was obtained using high-resolution ultrasound; biomarkers were assayed in different subsets of participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher chronic stress was associated with lower absolute FMD (mm FMD) in models adjusted for demographic and socioeconomic characteristics (0.169mm in high-stress participants vs. 0.178 and 0.179mm in medium and low-stress participants; P for trend = 0.04). This association remained unchanged with further adjustment for behavioral and biological CVD risk factors. Higher stress was related to higher ICAM-1 in models adjusted for sociodemographic characteristics and biological risk factors (P for trend = 0.005), but this association attenuated with adjustment for cigarette smoking (P for trend = 0.07). Chronic stress was not associated with E-selectin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Our findings suggest chronic stress is related to endothelial dysfunction, possibly in part through other stress-associated CVD risk factors such as cigarette smoking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpw103","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T22:44:40Z","timestamp":1472769880000},"page":"75-80","source":"Crossref","is-referenced-by-count":83,"title":["Chronic Stress and Endothelial Dysfunction: The Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1093","volume":"30","author":[{"given":"Kiarri N.","family":"Kershaw","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine 1 , Chicago, Illinois , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbi D.","family":"Lane-Cordova","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine 1 , Chicago, Illinois , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes R.","family":"Carnethon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine 1 , Chicago, Illinois , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary A.","family":"Tindle","sequence":"additional","affiliation":[{"name":"Vanderbilt Center for Tobacco, Addictions, and Lifestyle, Department of Medicine, Vanderbilt University Medical Center 2 , Nashville, Tennessee , USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine 1 , Chicago, Illinois , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2024020715443290200_CIT0001","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1001\/jama.298.14.1652","article-title":"Job strain and risk of acute recurrent coronary heart disease events","volume":"298","author":"Aboa-Eboul\u00e9","year":"2007","journal-title":"JAMA"},{"key":"2024020715443290200_CIT0002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/08964280209596039","article-title":"Psychosocial stress and cardiovascular disease: pathophysiological links","volume":"27","author":"Bairey Merz","year":"2002","journal-title":"Behav Med"},{"key":"2024020715443290200_CIT0003","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/aje\/kwi040","article-title":"Perceived job stress and incidence of coronary events: 3-year follow-up of 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