{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:49:20Z","timestamp":1761562160322,"version":"3.37.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["04-2012-0640"],"award-info":[{"award-number":["04-2012-0640"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Soluble forms of tumor necrosis factor receptors (sTNFRs) are emerging target molecules of inflammatory disease. However, their role in vascular biology is not well known. This study was performed to investigate the association between serum concentrations of sTNFRs and arterial stiffness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A total of 117 consecutive patients with suspected coronary artery disease (CAD) (63.6 \u00b1 11.0 years; men, 65%) who were referred for invasive coronary angiography (ICA) were prospectively enrolled. Arterial blood sTNFR1 and sTNFR2 were measured using commercially available ELISA kits. Brachial-ankle pulse wave velocity (baPWV) measurements were made within 24 hours of blood sampling for sTNFRs measurement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Most of the patients (86.3%) had significant CAD (stenosis \u2265 50%) in ICA. In simple linear regression analyses, there were significant positive correlations of baPWV with sTNFR1 (r = 0.483, P &amp;lt; 0.001) and sTNFR2 (r = 0.366, P &amp;lt; 0.001). In multiple linear regression analyses, sTNFR1 (\u03b2 = 0.316, P &amp;lt; 0.001) and sTNFR2 (\u03b2 = 0.235, P = 0.005) had independent association with baPWV even after controlling for potential confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>sTNFR1 and sTNFR2 were independently associated with baPWV in patients undergoing ICA. This result may extend previous knowledge on close interactions between inflammation and arterial stiffening.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpw134","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T19:06:19Z","timestamp":1476731179000},"page":"313-318","source":"Crossref","is-referenced-by-count":19,"title":["Soluble Tumor Necrosis Factor Receptors and Arterial Stiffness in Patients With Coronary Atherosclerosis"],"prefix":"10.1093","volume":"30","author":[{"given":"Hack-Lyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Nam","family":"An","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Hyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Bin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Kyu","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"},{"name":"Seoul National University Kidney Research Institute 3 , Seoul , Korea ;"},{"name":"Department of Medical Science 4 , Seoul National University College of Medicine, Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Hee","family":"Zo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center 1 , Seoul , Korea ;"},{"name":"Seoul National University College of Medicine 2 , Seoul , Korea ;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"2024020714271553700_CIT0001","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jacc.2010.12.017","article-title":"Aortic stiffness: current understanding and future directions","volume":"57","author":"Cavalcante","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2024020714271553700_CIT0002","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1253\/circj.CJ-10-0910","article-title":"Aging and arterial stiffness","volume":"74","author":"Lee","year":"2010","journal-title":"Circ J"},{"key":"2024020714271553700_CIT0003","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/hy0102.099031","article-title":"Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study","volume":"39","author":"Boutouyrie","year":"2002","journal-title":"Hypertension"},{"key":"2024020714271553700_CIT0004","doi-asserted-by":"crossref","first-page":"e0123164","DOI":"10.1371\/journal.pone.0123164","article-title":"The association of brachial-ankle pulse wave velocity with coronary artery disease evaluated by coronary computed tomography angiography","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"2024020714271553700_CIT0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/CIRCULATIONAHA.105.555235","article-title":"Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam study","volume":"113","author":"Mattace-Raso","year":"2006","journal-title":"Circulation"},{"key":"2024020714271553700_CIT0006","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: the Framingham Heart Study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"2024020714271553700_CIT0007","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/MNH.0b013e32835856e3","article-title":"Methods for assessing arterial stiffness: technical considerations","volume":"21","author":"Tomlinson","year":"2012","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2024020714271553700_CIT0008","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1291\/hypres.25.359","article-title":"Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement","volume":"25","author":"Yamashina","year":"2002","journal-title":"Hypertens Res"},{"key":"2024020714271553700_CIT0009","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jacc.2009.10.061","article-title":"Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis","volume":"55","author":"Vlachopoulos","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2024020714271553700_CIT0010","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1084\/jem.175.2.323","article-title":"Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors","volume":"175","author":"Aderka","year":"1992","journal-title":"J Exp Med"},{"key":"2024020714271553700_CIT0011","first-page":"371854","article-title":"Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy","volume":"2013","author":"Bremer","year":"2013","journal-title":"ISRN Oncol"},{"key":"2024020714271553700_CIT0012","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/rheumatology\/keq031","article-title":"Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents","volume":"49","author":"Horiuchi","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"2024020714271553700_CIT0013","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1056\/NEJMoa050516","article-title":"Infliximab for induction and maintenance therapy for ulcerative colitis","volume":"353","author":"Rutgeerts","year":"2005","journal-title":"N Engl J Med"},{"key":"2024020714271553700_CIT0014","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.atherosclerosis.2014.03.023","article-title":"Increased arterial stiffness in inflammatory bowel diseases is dependent upon inflammation and reduced by immunomodulatory drugs","volume":"234","author":"Zanoli","year":"2014","journal-title":"Atherosclerosis"},{"key":"2024020714271553700_CIT0015","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1161\/CIRCULATIONAHA.105.535435","article-title":"Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals","volume":"112","author":"Vlachopoulos","year":"2005","journal-title":"Circulation"},{"key":"2024020714271553700_CIT0016","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.ehj.2003.09.029","article-title":"Chronic inflammation and increased arterial stiffness in patients with cardiac syndrome X","volume":"24","author":"Arroyo-Espliguero","year":"2003","journal-title":"Eur Heart J"},{"key":"2024020714271553700_CIT0017","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3346\/jkms.2010.25.11.1616","article-title":"Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population","volume":"25","author":"Lee","year":"2010","journal-title":"J Korean Med Sci"},{"key":"2024020714271553700_CIT0018","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-7120-11-2","article-title":"The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population","volume":"11","author":"Kim","year":"2013","journal-title":"Cardiovasc Ultrasound"},{"key":"2024020714271553700_CIT0019","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3346\/jkms.2011.26.3.392","article-title":"A decline in renal function is associated with loss of bone mass in Korean postmenopausal women with mild renal dysfunction","volume":"26","author":"Kim","year":"2011","journal-title":"J Korean Med Sci"},{"key":"2024020714271553700_CIT0020","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/01.HYP.0000185463.27209.b0","article-title":"Arterial stiffness is related to systemic inflammation in essential hypertension","volume":"46","author":"Mahmud","year":"2005","journal-title":"Hypertension"},{"key":"2024020714271553700_CIT0021","doi-asserted-by":"crossref","first-page":"e94511","DOI":"10.1371\/journal.pone.0094511","article-title":"Increased arterial stiffness in systemic lupus erythematosus (SLE) patients at low risk for cardiovascular disease: a cross-sectional controlled study","volume":"9","author":"Sacre","year":"2014","journal-title":"PLoS One"},{"key":"2024020714271553700_CIT0022","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1161\/CIRCULATIONAHA.112.120410","article-title":"Anti-tumor necrosis factor-\u03b1 therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis","volume":"126","author":"M\u00e4ki-Pet\u00e4j\u00e4","year":"2012","journal-title":"Circulation"},{"key":"2024020714271553700_CIT0023","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.metabol.2006.12.007","article-title":"Soluble tumor necrosis factor receptor 2 is independently associated with pulse wave velocity in nonobese Japanese patients with type 2 diabetes mellitus","volume":"56","author":"Taniguchi","year":"2007","journal-title":"Metabolism"},{"key":"2024020714271553700_CIT0024","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/ajh.2009.79","article-title":"Soluble tumor necrosis factor receptor 1 level is associated with left ventricular hypertrophy: the northern Manhattan study","volume":"22","author":"Takei","year":"2009","journal-title":"Am J Hypertens"},{"key":"2024020714271553700_CIT0025","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-0039.2009.01332.x","article-title":"Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease","volume":"74","author":"Safranow","year":"2009","journal-title":"Tissue Antigens"},{"key":"2024020714271553700_CIT0026","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/hs0102.100531","article-title":"Tumor necrosis factor receptor levels are associated with carotid atherosclerosis","volume":"33","author":"Elkind","year":"2002","journal-title":"Stroke"},{"key":"2024020714271553700_CIT0027","doi-asserted-by":"crossref","first-page":"e55477","DOI":"10.1371\/journal.pone.0055477","article-title":"Soluble TNF receptors are associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction","volume":"8","author":"Nilsson","year":"2013","journal-title":"PLoS One"},{"key":"2024020714271553700_CIT0028","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.CIR.0000155614.35441.69","article-title":"Tumor necrosis factor-alpha receptor 1 is a major predictor of mortality and new-onset heart failure in patients with acute myocardial infarction: the Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) study","volume":"111","author":"Valgimigli","year":"2005","journal-title":"Circulation"},{"key":"2024020714271553700_CIT0029","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2337\/diacare.28.6.1376","article-title":"A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes","volume":"28","author":"Shai","year":"2005","journal-title":"Diabetes Care"},{"key":"2024020714271553700_CIT0030","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/01.CIR.92.6.1479","article-title":"Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure","volume":"92","author":"Ferrari","year":"1995","journal-title":"Circulation"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/30\/3\/313\/56611446\/hpw134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/30\/3\/313\/56611446\/hpw134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T17:37:28Z","timestamp":1707327448000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/30\/3\/313\/2645505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,7]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,12,7]]},"published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpw134","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"type":"print","value":"0895-7061"},{"type":"electronic","value":"1941-7225"}],"subject":[],"published-other":{"date-parts":[[2017,3,1]]},"published":{"date-parts":[[2016,12,7]]}}}