{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:56:58Z","timestamp":1760122618775},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Angiopoietin-like-2 (ANGPTL2) is a secreted proinflammatory glycoprotein that promotes endothelial dysfunction, atherosclerosis, and cardiovascular disease (CVD). Circulating ANGPTL2 is increased in chronic kidney disease (CKD), where the risk of CVD is amplified. The objectives of the present study were to (i) examine whether kidney transplantation (KTx) reduces ANGPTL2 levels, (ii) identify the determinants of ANGPTL2 after KTx, (iii) study the association of ANGPTL2 with aortic stiffness, and (iv) assess the impact of ANGPTL2 on mortality after KTx.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In 75 patients, serum ANGPTL2 levels were measured at baseline and 3 months after KTx. Aortic stiffness was determined by carotid-femoral pulse wave velocity, glomerular filtration rate was estimated by CKD-EPI formula, and serum cytokines and endothlin-1 levels were determined 3 months after KTx. Survival analysis was performed using Kaplan\u2013Meier and Cox regression after a median follow-up of 90 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After 3 months of KTx, ANGPTL2 levels decreased from 71 ng\/ml (53\u201395) to 11 ng\/ml (9\u201315) (P &amp;lt; 0.001). In multivariate analysis, age, lower renal function, and endothelin-1 were independently associated with higher post-KTx ANGPTL2 levels. ANGPTL2 was positively associated with aortic stiffness after KTx, even when adjusted for mean blood pressure (standardized \u03b2 = 0.314; P = 0.008). During follow-up, 13 deaths occurred. The group of patients with higher post-KTx ANGPTL2 levels had a hazard ratio for mortality of 3.9 (95% confidence interval: 1.07\u201314.4; P = 0.039).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>KTx significantly reduced serum ANGPTL2 levels. The positive association between post-KTx ANGPTL2, aortic stiffness and mortality, suggests that ANGPTL2 may play a biological role in CKD-related CVD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpw208","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:05:55Z","timestamp":1483646755000},"page":"409-416","source":"Crossref","is-referenced-by-count":14,"title":["Levels of Angiopoietin-Like-2 Are Positively Associated With Aortic Stiffness and Mortality After Kidney Transplantation"],"prefix":"10.1093","volume":"30","author":[{"given":"Marie-Pier","family":"Desjardins","sequence":"first","affiliation":[{"name":"CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec hospital, Division of Nephrology, Department of medicine, Faculty of medicine, Universit\u00e9 Laval 1 , Qu\u00e9bec City, Qu\u00e9bec , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Thorin-Trescases","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, Montreal Heart Institute, Department of Surgery 2 , Montr\u00e9al, Qu\u00e9bec , Canada ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aboubacar","family":"Sidib\u00e9","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec hospital, Division of Nephrology, Department of medicine, Faculty of medicine, Universit\u00e9 Laval 1 , Qu\u00e9bec City, Qu\u00e9bec , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Fortier","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec hospital, Division of Nephrology, Department of medicine, Faculty of medicine, Universit\u00e9 Laval 1 , Qu\u00e9bec City, Qu\u00e9bec , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sacha A.","family":"De Serres","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec hospital, Division of Nephrology, Department of medicine, Faculty of medicine, Universit\u00e9 Laval 1 , Qu\u00e9bec City, Qu\u00e9bec , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Larivi\u00e8re","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec hospital, Division of Nephrology, Department of medicine, Faculty of medicine, Universit\u00e9 Laval 1 , Qu\u00e9bec City, Qu\u00e9bec , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Thorin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, Montreal Heart Institute, Department of Surgery 2 , Montr\u00e9al, Qu\u00e9bec , Canada ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Agharazii","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec hospital, Division of Nephrology, Department of medicine, Faculty of medicine, Universit\u00e9 Laval 1 , Qu\u00e9bec City, Qu\u00e9bec , Canada ;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"2024020714260997100_CIT0001","first-page":"S16","article-title":"Epidemiology of cardiovascular disease in chronic renal disease","volume":"9","author":"Foley","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"2024020714260997100_CIT0002","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N 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