{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:57:55Z","timestamp":1793145475445,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Macrophage migration inhibitory factor (MIF) is an intracellular inhibitory regulator of the actions of angiotensin II in the central nervous system. Renovascular hypertensive 2-kidney, 1-clip (2K1C) rats have an increased activity of the renin\u2013angiotensin system and a decrease in baroreflex function compared to normotensive (NT) rats. In the present study, we tested the effects of MIF overexpression within the nucleus of the solitary tract (NTS), a key brainstem region for cardiovascular regulation, on the development of hypertension, on baroreflex function, and on water and food intake in 2K1C rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Holtzman NT rats received a silver clip around the left renal artery to induce 2K1C hypertension. Three weeks later, rats were microinjected in the NTS with AAV2-CBA-MIF, to increase the expression of MIF, or with the control vector AAV2-CBA-enhanced green fluorescent protein. Mean arterial pressure (MAP) and heart rate were recorded by telemetry. Baroreflex function was tested, and water and food intake were also measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Increasing MIF expression in the NTS of 2K1C rats attenuated the development of hypertension, reversed the impairment of baroreflex function, and reduced the increase in water intake. In contrast to 2K1C rats, similar increases in MIF expression in the NTS of NT rats produced no changes in baseline MAP, baroreflex function, or water intake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These results indicate that an increased expression of MIF within the NTS attenuates the development of hypertension and restores the baroreflex function in 2K1C rats.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpx001","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T12:06:08Z","timestamp":1483445168000},"page":"435-443","source":"Crossref","is-referenced-by-count":17,"title":["Increased Expression of Macrophage Migration Inhibitory Factor in the Nucleus of the Solitary Tract Attenuates Renovascular Hypertension in Rats"],"prefix":"10.1093","volume":"30","author":[{"given":"Rafaela Moreira","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathology, School of Dentistry, S\u00e3o Paulo State University 1 , Araraquara, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme F.","family":"Speretta","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, School of Dentistry, S\u00e3o Paulo State University 1 , Araraquara, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Penteado Martins","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo 2 , Ribeir\u00e3o Preto, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant Jay","family":"Ruchaya","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, School of Dentistry, S\u00e3o Paulo State University 1 , Araraquara, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Southern Medical University 3 , Guangzhou , China ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Vanderlei","family":"Menani","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, School of Dentistry, S\u00e3o Paulo State University 1 , Araraquara, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Sumners","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Genomics, College of Medicine, University of Florida 4 , Gainesville, Florida , USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Colombari","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, School of Dentistry, S\u00e3o Paulo State University 1 , Araraquara, S\u00e3o Paulo , Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora S. 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