{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:18:28Z","timestamp":1787242708831,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Magnesium sulfate (MgSO4) is used as a prophylaxis for eclamptic seizures. The exact mechanism of action is not fully established. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to investigate if cerebral magnesium (Mg2+) levels differ between women with preeclampsia, normal pregnant, and nonpregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This cross-sectional study comprised 28 women with preeclampsia, 30 women with normal pregnancies in corresponding gestational week (range: 23\u201341 weeks) and 11 nonpregnant healthy controls. All women underwent 31P-MRS from the parieto-occipital region of the brain and were interviewed about cerebral symptoms. Differences between groups were assessed by analysis of variance and Tukey\u2019s post-hoc test. Correlations between Mg2+ levels and specific neurological symptoms were estimated with Spearman\u2019s rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mean maternal cerebral Mg2+ levels were lower in women with preeclampsia (0.12 mM \u00b1 0.02) compared to normal pregnant controls (0.14 mM \u00b1 0.03) (P = 0.04). Nonpregnant and normal pregnant women did not differ in Mg2+ levels. Among women with preeclampsia, lower Mg2+ levels correlated with presence of visual disturbances (P = 0.04). Plasma levels of Mg2+ did not differ between preeclampsia and normal pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Women with preeclampsia have reduced cerebral Mg2+ levels, which could explain the potent antiseizure prophylactic properties of MgSO4. Within the preeclampsia group, women with visual disturbances have lower levels of Mg2+ than those without such symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpx022","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T08:25:10Z","timestamp":1485764710000},"page":"667-672","source":"Crossref","is-referenced-by-count":19,"title":["Cerebral Magnesium Levels in Preeclampsia; A Phosphorus Magnetic Resonance Spectroscopy Study"],"prefix":"10.1093","volume":"30","author":[{"given":"Maria","family":"Nelander","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University 1 , Uppsala , Sweden ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Weis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Uppsala University 2 , Uppsala , Sweden ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University 1 , Uppsala , Sweden ;"},{"name":"Center for Clinical Research 3 , Dalarna , Sweden ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University 4 , Uppsala , Sweden ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University 1 , Uppsala , Sweden ;"},{"name":"Department of Clinical Sciences, Karolinska Institute 5 , Danderyd Hospital, Stockholm , Sweden ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Radiology, Uppsala University 2 , Uppsala , Sweden ;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"2022112110394648300_CIT0001","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/S0140-6736(02)08778-0","article-title":"Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial","volume":"359","author":"Altman","year":"2002","journal-title":"Lancet (London, England)"},{"key":"2022112110394648300_CIT0002","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/STROKEAHA.108.527788","article-title":"Magnesium sulfate for the treatment of eclampsia: a brief review","volume":"40","author":"Euser","year":"2009","journal-title":"Stroke"},{"key":"2022112110394648300_CIT0003","doi-asserted-by":"crossref","first-page":"e113670","DOI":"10.1371\/journal.pone.0113670","article-title":"Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia","volume":"9","author":"Johnson","year":"2014","journal-title":"PloS One"},{"key":"2022112110394648300_CIT0004","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/AOG.0b013e3182324570","article-title":"Characterization of symptoms immediately preceding eclampsia","volume":"118","author":"Cooray","year":"2011","journal-title":"Obstet Gynecol"},{"key":"2022112110394648300_CIT0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1099-1492(199602)9:1<24::AID-NBM392>3.0.CO;2-B","article-title":"In vivo assessment of free magnesium concentration in human brain by 31P MRS. A new calibration curve based on a mathematical algorithm","volume":"9","author":"Iotti","year":"1996","journal-title":"NMR Biomed"},{"key":"2022112110394648300_CIT0006","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/01.HYP.0000137592.76535.8c","article-title":"Cellular-free magnesium depletion in brain and muscle of normal and preeclamptic pregnancy: a nuclear magnetic resonance spectroscopic study","volume":"44","author":"Resnick","year":"2004","journal-title":"Hypertension"},{"key":"2022112110394648300_CIT0007","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.preghy.2012.11.001","article-title":"The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"3","author":"Tranquilli","year":"2013","journal-title":"Pregnancy Hypertens"},{"key":"2022112110394648300_CIT0008","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1651-2227.1996.tb14164.x","article-title":"Intrauterine growth curves based on ultrasonically estimated foetal weights","volume":"85","author":"Marsal","year":"1996","journal-title":"Acta Paediatr"},{"key":"2022112110394648300_CIT0009","first-page":"283","article-title":"Image-selected in Vivo spectroscopy (ISIS). A new technique for spatially selective nmr spectroscopy","volume":"66","author":"Ordidge","year":"1986","journal-title":"J Magn Reson"},{"key":"2022112110394648300_CIT0010","first-page":"141","article-title":"Java-based graphical user interface for the MRUI quantitation package","volume":"12","author":"Naressi","year":"2001","journal-title":"Magma (New York, NY)"},{"key":"2022112110394648300_CIT0011","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/jmre.1997.1244","article-title":"Improved method for accurate and efficient quantification of MRS data with use of prior knowledge","volume":"129","author":"Vanhamme","year":"1997","journal-title":"J Magn Reson (San Diego, Calif : 1997)"},{"key":"2022112110394648300_CIT0012","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.bb.13.060184.001253","article-title":"NMR studies of intracellular metal ions in intact cells and tissues","volume":"13","author":"Gupta","year":"1984","journal-title":"Annu Rev Biophys Bioeng"},{"key":"2022112110394648300_CIT0013","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199602223340803","article-title":"A reversible posterior leukoencephalopathy syndrome","volume":"334","author":"Hinchey","year":"1996","journal-title":"New Engl J Med"},{"key":"2022112110394648300_CIT0014","doi-asserted-by":"crossref","first-page":"468 e1","DOI":"10.1016\/j.ajog.2013.02.015","article-title":"Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia","volume":"208","author":"Brewer","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"2022112110394648300_CIT0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/bja\/75.1.51","article-title":"Effect of labetalol on cerebral blood flow, oxygen metabolism and autoregulation in healthy humans","volume":"75","author":"Olsen","year":"1995","journal-title":"Br J Anaesth"},{"key":"2022112110394648300_CIT0016","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1081\/PRG-120015845","article-title":"Labetalol decreases cerebral perfusion pressure without negatively affecting cerebral blood flow in hypertensive gravidas","volume":"21","author":"Belfort","year":"2002","journal-title":"Hypertens Pregnancy"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/30\/7\/667\/47160427\/ajh_30_7_667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/30\/7\/667\/47160427\/ajh_30_7_667.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T05:40:18Z","timestamp":1669009218000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/30\/7\/667\/3039419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,2,21]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpx022","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,2,21]]}}}