{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:02:36Z","timestamp":1769115756021,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Hypertension control in Hispanics\/Latinos lag behind general US trends by 10\u201315%. Intensive systolic blood pressure (SBP) management &amp;lt;120 mm Hg may significantly reduce morbidity\/mortality risk in adults with hypertension; less is known about cognition. We investigated cross-sectional associations of cognition with observed hypertension control at currently recommended (SBP &amp;lt; 140 mm Hg) and more intensive (SBP &amp;lt; 120 mm Hg) levels using baseline data from the Hispanic Community Health Study\/Study of Latinos.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>From this multicenter cohort study, we focused on 1,735 Hispanic\/Latino men and women ages 45\u201374 years with hypertension and verified antihypertensive use. Verbal fluency, information processing speed, learning, and memory were tested in Spanish or English.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Separate linear regressions revealed that being on 1 vs. &amp;gt;1 antihypertensive medication was not associated with cognition; however, individuals with SBP controlled to currently recommended levels outperformed individuals with uncontrolled SBP on verbal fluency [Beta = 1.44 (0.52), P &amp;lt; 0.01] and information processing speed [Beta = 3.01 (0.89), P &amp;lt; 0.001] in age-adjusted regression analyses; only information processing speed remained significant (P &amp;lt; 0.05) after additional adjustments including acculturation, health insurance, and other cardiovascular disease risk factors. When regrouping individuals based on more intensive SBP control, individuals with levels &amp;lt;120 mm Hg outperformed individuals with higher SBP on verbal fluency regardless of adjustments (P &amp;lt; 0.01). More intensive rather than currently recommended levels of control associated with higher verbal fluency performance regardless of adjustments (P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Individual cognitive test scores related to distinct SBP management with more intensive management appearing more robust against confounders. While cognitive associations with hypertension in Hispanics\/Latinos may be multifactorial, different levels of SBP control should be considered in future prospective intervention studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpx023","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T08:56:05Z","timestamp":1487148965000},"page":"624-631","source":"Crossref","is-referenced-by-count":13,"title":["Cognitive Associates of Current and More Intensive Control of Hypertension: Findings From the Hispanic Community Health Study\/Study of Latinos"],"prefix":"10.1093","volume":"30","author":[{"given":"Melissa","family":"Lamar","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Illinois at Chicago 1 , Chicago, Illinois , USA ;"},{"name":"Institute for Minority Health Research, University of Illinois at Chicago 2 , Chicago, Illinois , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Minority Health Research, University of Illinois at Chicago 2 , Chicago, Illinois , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon A.","family":"Durazo-Arvizu","sequence":"additional","affiliation":[{"name":"Institute for Minority Health Research, University of Illinois at Chicago 2 , Chicago, Illinois , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain and the Gertrude H. Sergievsky Center, Columbia University 3 , New York, New York , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Michigan State University 4 , East Lansing, Michigan , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Tarraf","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, Wayne State University 5 , Detroit, Michigan , USA ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha L.","family":"Daviglus","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Illinois at Chicago 1 , Chicago, Illinois , USA ;"},{"name":"Institute for Minority Health Research, University of Illinois at Chicago 2 , Chicago, Illinois , USA ;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"2022112111211023600_CIT0001","volume-title":"Health Disparities and Inequalities Report","year":"2013"},{"key":"2022112111211023600_CIT0002","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/HYPERTENSIONAHA.109.147389","article-title":"Lowering midlife levels of systolic blood pressure as a public health strategy to reduce late-life dementia: perspective from the Honolulu Heart Program\/Honolulu Asia Aging Study","volume":"55","author":"Launer","year":"2010","journal-title":"Hypertension"},{"key":"2022112111211023600_CIT0003","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1212\/WNL.0b013e318227b227","article-title":"Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline","volume":"77","author":"Debette","year":"2011","journal-title":"Neurology"},{"key":"2022112111211023600_CIT0004","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/ajmg.b.30694","article-title":"Diabetes and overweight associate with non-APOE4 genotype in an Alzheimer\u2019s disease population","volume":"147B","author":"Profenno","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"2022112111211023600_CIT0005","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1159\/000324134","article-title":"Type 2 diabetes and late-onset Alzheimer\u2019s disease","volume":"31","author":"Cheng","year":"2011","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2022112111211023600_CIT0006","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/jamaneurol.2014.1646","article-title":"Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study","volume":"71","author":"Gottesman","year":"2014","journal-title":"JAMA Neurol"},{"key":"2022112111211023600_CIT0007","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1038\/tp.2012.28","article-title":"Antihypertensives for combating dementia? 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