{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:54:22Z","timestamp":1783619662691,"version":"3.55.0"},"reference-count":119,"publisher":"Oxford University Press (OUP)","issue":"11","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13SDG17050056"],"award-info":[{"award-number":["13SDG17050056"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"DOI":"10.1093\/ajh\/hpx063","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T23:28:50Z","timestamp":1490225330000},"page":"1053-1062","source":"Crossref","is-referenced-by-count":27,"title":["New Models of Pregnancy-Associated Hypertension"],"prefix":"10.1093","volume":"30","author":[{"given":"Spencer C","family":"Cushen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Goulopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"key\n\t\t\t\t20171009051724_CIT0001","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/aji.12460","article-title":"Inventory of novel animal models addressing etiology of preeclampsia in the development of new therapeutic\/intervention opportunities","volume":"75","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0002","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.placenta.2011.03.010","article-title":"Animal models of preeclampsia; uses and limitations","volume":"32","year":"2011","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20171009051724_CIT0003","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.preghy.2014.01.003","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy","volume":"4","author":"Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"key\n\t\t\t\t20171009051724_CIT0004","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1161\/CIRCULATIONAHA.111.044784","article-title":"Associations of pregnancy complications with calculated cardiovascular disease risk and cardiovascular risk factors in middle age: the Avon Longitudinal Study of Parents and Children","volume":"125","year":"2012","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171009051724_CIT0005","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.jacc.2011.02.005","article-title":"Effectiveness-based guidelines for the prevention of cardiovascular disease in women\u20132011 update: a guideline from the American Heart Association","volume":"57","author":"American Heart Association","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0006","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.109.853127","article-title":"Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease","volume":"123","year":"2011","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171009051724_CIT0007","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11906-016-0633-x","article-title":"Placental ischemia and resultant phenotype in animal models of preeclampsia","volume":"18","year":"2016","journal-title":"Curr Hypertens Rep"},{"key":"key\n\t\t\t\t20171009051724_CIT0008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dmm.008516","article-title":"Preeclampsia: multiple approaches for a multifactorial disease","volume":"5","year":"2012","journal-title":"Dis Model Mech"},{"key":"key\n\t\t\t\t20171009051724_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2014.02.006","article-title":"The use and misuse of animal analog models of human pregnancy disorders","volume":"103","year":"2014","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0010","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1095\/biolreprod.102.009886","article-title":"Pregnancy-induced alterations of vascular function in mouse mesenteric and uterine arteries","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009051724_CIT0011","article-title":"Mechanisms of uterine artery dysfunction in pregnancy complications","year":"2017","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20171009051724_CIT0012","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/physiol.00033.2008","article-title":"Maternal uterine vascular remodeling during pregnancy","volume":"24","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"key\n\t\t\t\t20171009051724_CIT0013","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ki.1991.36","article-title":"Osmoregulation of thirst and vasopressin release in severe chronic renal failure","volume":"39","year":"1991","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20171009051724_CIT0014","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1447-0756.2010.01498.x","article-title":"Circulating levels of copeptin, a novel biomarker in pre-eclampsia","volume":"37","year":"2011","journal-title":"J Obstet Gynaecol Res"},{"key":"key\n\t\t\t\t20171009051724_CIT0015","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.114.03848","article-title":"Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model","volume":"64","year":"2014","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0016","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1161\/HYPERTENSIONAHA.114.03762","article-title":"Increased levels of copeptin before clinical diagnosis of preelcampsia","volume":"64","year":"2014","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0017","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1152\/ajpregu.00377.2014","article-title":"The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia","volume":"309","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0018","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/HYPERTENSIONAHA.115.06071","article-title":"Sildenafil treatment ameliorates the maternal syndrome of preeclampsia and rescues fetal growth in the Dahl salt-sensitive rat","volume":"67","year":"2016","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0019","doi-asserted-by":"crossref","first-page":"e0125499","DOI":"10.1371\/journal.pone.0125499","article-title":"A1M ameliorates preeclampsia-like symptoms in placenta and kidney induced by cell-free fetal hemoglobin in rabbit","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171009051724_CIT0020","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.fertnstert.2007.09.030","article-title":"Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes","volume":"90","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171009051724_CIT0021","doi-asserted-by":"crossref","first-page":"520.e1","DOI":"10.1016\/j.ajog.2011.01.058","article-title":"Fetal hemoglobin and \u03b11-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia","volume":"204","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0022","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.placenta.2011.01.017","article-title":"Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by \u03b11-microglobulin","volume":"32","year":"2011","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20171009051724_CIT0023","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrm3065","article-title":"HTRA proteases: regulated proteolysis in protein quality control","volume":"12","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20171009051724_CIT0024","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1097-2765(02)00658-5","article-title":"The HtrA family of proteases: implications for protein composition and cell fate","volume":"10","year":"2002","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20171009051724_CIT0025","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1073\/pnas.0501823102","article-title":"Implications of the serine protease HtrA1 in amyloid precursor protein processing","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171009051724_CIT0026","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1133807","article-title":"HTRA1 promoter polymorphism in wet age-related macular degeneration","volume":"314","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20171009051724_CIT0027","first-page":"2724","article-title":"High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling","volume":"60","year":"2016","journal-title":"Eur J Histochem"},{"key":"key\n\t\t\t\t20171009051724_CIT0028","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1369\/jhc.4A6330.2004","article-title":"Pattern of expression of HtrA1 during mouse development","volume":"52","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20171009051724_CIT0029","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/molehr\/gag036","article-title":"A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation","volume":"9","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20171009051724_CIT0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ydbio.2014.10.015","article-title":"Abnormal development of placenta in HtrA1-deficient mice","volume":"397","year":"2015","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20171009051724_CIT0031","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/smim.2000.0317","article-title":"Extinguishing maternal immune responses during pregnancy: implications for immunosuppression","volume":"13","year":"2001","journal-title":"Semin Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0032","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1179\/135100099101534927","article-title":"Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway","volume":"4","year":"1999","journal-title":"Redox Rep"},{"key":"key\n\t\t\t\t20171009051724_CIT0033","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1067\/mob.2003.156","article-title":"Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia","volume":"188","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0034","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/plac.2002.0818","article-title":"Localization of indoleamine 2,3-dioxygenase and 4-hydroxynonenal in normal and pre-eclamptic placentae","volume":"23","year":"2002","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20171009051724_CIT0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0897.2007.00484.x","article-title":"The etiological role of allogeneic fetal rejection in pre-eclampsia","volume":"58","year":"2007","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0036","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jri.2017.01.003","article-title":"Downregulation of indoleamine 2, 3-dioxygenase expression in the villous stromal endothelial cells of placentas with preeclampsia","volume":"119","year":"2017","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0037","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20171009051724_CIT0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1447-0756.2007.00679.x","article-title":"Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia","volume":"34","year":"2008","journal-title":"J Obstet Gynaecol Res"},{"key":"key\n\t\t\t\t20171009051724_CIT0039","article-title":"Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes","volume":"3","year":"2015","journal-title":"Physiol Rep"},{"key":"key\n\t\t\t\t20171009051724_CIT0040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/cpr.12174","article-title":"Transcription factor STOX1 regulates proliferation of inner ear epithelial cells via the AKT pathway","volume":"48","year":"2015","journal-title":"Cell Prolif"},{"key":"key\n\t\t\t\t20171009051724_CIT0041","doi-asserted-by":"crossref","first-page":"736","DOI":"10.4161\/epi.5.8.13084","article-title":"Differential methylation of STOX1 in human placenta","volume":"5","year":"2010","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20171009051724_CIT0042","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1093\/hmg\/ddq152","article-title":"The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation","volume":"19","year":"2010","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20171009051724_CIT0043","doi-asserted-by":"crossref","first-page":"e3905","DOI":"10.1371\/journal.pone.0003905","article-title":"STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas","volume":"3","year":"2008","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171009051724_CIT0044","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/ars.2013.5661","article-title":"Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene","volume":"21","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20171009051724_CIT0045","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/HYPERTENSIONAHA.111.202994","article-title":"Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment","volume":"61","year":"2013","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0046","doi-asserted-by":"crossref","first-page":"19196","DOI":"10.1038\/srep19196","article-title":"Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia","volume":"6","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20171009051724_CIT0047","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1124\/pr.114.010090","article-title":"Toll-like receptors in the vascular system: sensing the dangers within","volume":"68","year":"2016","journal-title":"Pharmacol Rev"},{"key":"key\n\t\t\t\t20171009051724_CIT0048","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/aji.12258","article-title":"Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy complications","volume":"72","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0049","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.vaccine.2005.07.105","article-title":"Maternal treatment with a high dose of CpG ODN during gestation alters fetal craniofacial and distal limb development in C57BL\/6 mice","volume":"24","year":"2006","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20171009051724_CIT0050","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.4049\/jimmunol.1103454","article-title":"TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia","volume":"188","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0051","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.4049\/jimmunol.0900788","article-title":"TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes","volume":"183","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0052","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/ajh.2009.185","article-title":"Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats","volume":"22","year":"2009","journal-title":"Am J Hypertens"},{"key":"key\n\t\t\t\t20171009051724_CIT0053","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/HYPERTENSIONAHA.111.172114","article-title":"Interleukin 10 deficiency exacerbates Toll-like receptor 3-induced preeclampsia-like symptoms in mice","volume":"58","year":"2011","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0054","doi-asserted-by":"crossref","first-page":"e41884","DOI":"10.1371\/journal.pone.0041884","article-title":"Placental Toll-like receptor 3 and Toll-like receptor 7\/8 activation contributes to preeclampsia in humans and mice","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171009051724_CIT0055","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/HYPERTENSIONAHA.110.163329","article-title":"A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice","volume":"57","year":"2011","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0056","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ajh\/hpu100","article-title":"Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice","volume":"28","year":"2015","journal-title":"Am J Hypertens"},{"key":"key\n\t\t\t\t20171009051724_CIT0057","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/CS20150555","article-title":"Human placenta-derived stromal cells decrease inflammation, placental injury and blood pressure in hypertensive pregnant mice","volume":"130","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"key\n\t\t\t\t20171009051724_CIT0058","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2567.1997.00139.x","article-title":"Localization of IL-4 and IL-4 receptors in the human term placenta, decidua and amniochorionic membranes","volume":"90","year":"1997","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20171009051724_CIT0059","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1097\/HJH.0b013e328360ae6c","article-title":"Interleukin-4 deficiency induces mild preeclampsia in mice","volume":"31","year":"2013","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t20171009051724_CIT0060","doi-asserted-by":"crossref","first-page":"H1015","DOI":"10.1152\/ajpheart.00834.2015","article-title":"Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats","volume":"310","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0061","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0002-9378(94)90463-4","article-title":"A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats","volume":"171","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0062","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0140-6736(90)90869-7","article-title":"Thromboxane A2 synthesis in pregnancy-induced hypertension","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171009051724_CIT0063","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0020-7292(98)00101-5","article-title":"Thromboxane and prostacyclin in maternal and fetal circulation in pre-eclampsia","volume":"63","year":"1998","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t20171009051724_CIT0064","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","author":"American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy","year":"2013","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0065","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/M14-1884","article-title":"Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement","volume":"161","author":"U.S. Preventive Services Task Force","year":"2014","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20171009051724_CIT0066","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0022-2143(97)90126-8","article-title":"Aspirin treatment of the low-dose-endotoxin-treated pregnant rat: pathophysiologic and immunohistologic aspects","volume":"130","year":"1997","journal-title":"J Lab Clin Med"},{"key":"key\n\t\t\t\t20171009051724_CIT0067","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3109\/10641950903242659","article-title":"Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis","volume":"29","author":"Toxaemia Study Group","year":"2010","journal-title":"Hypertens Pregnancy"},{"key":"key\n\t\t\t\t20171009051724_CIT0068","doi-asserted-by":"crossref","first-page":"e0124001","DOI":"10.1371\/journal.pone.0124001","article-title":"Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171009051724_CIT0069","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2016.03.002","article-title":"Curcumin improves LPS-induced preeclampsia-like phenotype in rat by inhibiting the TLR4 signaling pathway","volume":"41","year":"2016","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20171009051724_CIT0070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/hy02t2.102904","article-title":"Discovery of a spontaneous genetic mouse model of preeclampsia","volume":"39","year":"2002","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0071","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1095\/biolreprod.106.053603","article-title":"Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia","volume":"75","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009051724_CIT0072","first-page":"e75351","article-title":"Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model","volume":"1","year":"2016","journal-title":"JCI Insight"},{"key":"key\n\t\t\t\t20171009051724_CIT0073","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/HYPERTENSIONAHA.110.160242","article-title":"Adenoviral delivery of VEGF121 early in pregnancy prevents spontaneous development of preeclampsia in BPH\/5 mice","volume":"57","year":"2011","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0074","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.niox.2013.07.006","article-title":"Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia","volume":"33","year":"2013","journal-title":"Nitric Oxide"},{"key":"key\n\t\t\t\t20171009051724_CIT0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.niox.2014.07.006","article-title":"Polymorphisms in endothelial nitric oxide synthase gene in early and late severe preeclampsia","volume":"42","year":"2014","journal-title":"Nitric Oxide"},{"key":"key\n\t\t\t\t20171009051724_CIT0076","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/bcp.12301","article-title":"The nitric oxide pathway and possible therapeutic options in pre-eclampsia","volume":"78","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"key\n\t\t\t\t20171009051724_CIT0077","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0002-9378(13)90488-9","article-title":"Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation","volume":"170","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0078","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/01.HYP.26.6.1019","article-title":"Effects of long-term nitric oxide synthesis inhibition on plasma volume expansion and fetal growth in the pregnant rat","volume":"26","year":"1995","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0079","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/rda.12536","article-title":"Effect of sildenafil on pre-eclampsia-like mouse model induced by L-NAME","volume":"50","year":"2015","journal-title":"Reprod Domest Anim"},{"key":"key\n\t\t\t\t20171009051724_CIT0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2016.12.010","article-title":"The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia","volume":"795","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20171009051724_CIT0081","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1067\/mob.2001.118142","article-title":"Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy","volume":"185","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0082","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","year":"1995","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171009051724_CIT0083","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1177\/1933719115625839","article-title":"Endothelin receptor A antagonism and fetal growth in endothelial nitric oxide synthase gene knockout maternal and fetal mice","volume":"23","year":"2016","journal-title":"Reprod Sci"},{"key":"key\n\t\t\t\t20171009051724_CIT0084","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1540\/jsmr.39.67","article-title":"Phosphodiesterases in the vascular system","volume":"39","year":"2003","journal-title":"J Smooth Muscle Res"},{"key":"key\n\t\t\t\t20171009051724_CIT0085","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10641950802601278","article-title":"A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia","volume":"28","year":"2009","journal-title":"Hypertens Pregnancy"},{"key":"key\n\t\t\t\t20171009051724_CIT0086","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/AOG.0000000000001518","article-title":"Perinatal and hemodynamic evaluation of sildenafil citrate for preeclampsia treatment: a randomized controlled trial","volume":"128","year":"2016","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0087","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejogrb.2009.11.005","article-title":"Sildenafil citrate improves fetal outcomes in pregnant, L-NAME treated, Sprague-Dawley rats","volume":"149","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171009051724_CIT0088","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjp.0707131","article-title":"Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat","volume":"150","year":"2007","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20171009051724_CIT0089","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-0032-1304823","article-title":"Effects of sildenafil in N\u03c9-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model","volume":"29","year":"2012","journal-title":"Am J Perinatol"},{"key":"key\n\t\t\t\t20171009051724_CIT0090","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0002-9378(81)90512-3","article-title":"A simplified technique to produce toxemia in the pregnant dog","volume":"139","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0091","first-page":"R1558","article-title":"Importance of prostaglandins in hypertension during reduced uteroplacental perfusion pressure","volume":"257","year":"1989","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0092","first-page":"R204","article-title":"Role of the renin-angiotensin system in hypertension during reduced uteroplacental perfusion pressure","volume":"257","year":"1989","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0093","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/0002-9378(76)90493-2","article-title":"Placental lesions in experimental toxemia in the rabbit","volume":"125","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0094","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0002-9378(76)90169-1","article-title":"Production of experimental toxemia in the pregnant rabbit","volume":"124","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00000441-199204000-00005","article-title":"Increased peripheral resistance during reduced uterine perfusion pressure hypertension in pregnant rabbits","volume":"303","year":"1992","journal-title":"Am J Med Sci"},{"key":"key\n\t\t\t\t20171009051724_CIT0096","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0002-9378(86)90111-0","article-title":"Pregnancy-induced hypertension: development of a model in the pregnant sheep","volume":"155","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0097","first-page":"174","article-title":"Experimental toxemia in the pregnant guinea pig (Cavia porcellus)","volume":"30","year":"1980","journal-title":"Lab Anim Sci"},{"key":"key\n\t\t\t\t20171009051724_CIT0098","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0002-9378(93)90171-E","article-title":"Experimental preeclampsia produced by chronic constriction of the lower aorta: validation with longitudinal blood pressure measurements in conscious rhesus monkeys","volume":"169","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0099","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0002-9378(93)90172-F","article-title":"Increased depth of trophoblast invasion after chronic constriction of the lower aorta in rhesus monkeys","volume":"169","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0100","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0002-9378(85)90679-9","article-title":"Pregnancy-induced hypertension: development of a model in the pregnant primate (Papio anubis)","volume":"151","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0101","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1","volume":"71","year":"2007","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20171009051724_CIT0102","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-9378(67)90448-6","article-title":"Chronic uterine ischemia and reversible experimental \u201ctoxemia of pregnancy\u201d","volume":"97","year":"1967","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171009051724_CIT0103","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/eji.200324469","article-title":"Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice","volume":"34","year":"2004","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20171009051724_CIT0104","first-page":"14873","article-title":"CD4+ T cells play a critical role in mediating hypertension in response to placental ischemia","volume":"2","year":"2013","journal-title":"J Hypertens (Los Angel)"},{"key":"key\n\t\t\t\t20171009051724_CIT0105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/10641955.2015.1032054","article-title":"IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia","volume":"34","year":"2015","journal-title":"Hypertens Pregnancy"},{"key":"key\n\t\t\t\t20171009051724_CIT0106","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1161\/HYPERTENSIONAHA.110.168344","article-title":"CD4+ T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancy","volume":"57","year":"2011","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0107","doi-asserted-by":"crossref","first-page":"R884","DOI":"10.1152\/ajpregu.00154.2015","article-title":"An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia","volume":"309","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0108","doi-asserted-by":"crossref","first-page":"R1353","DOI":"10.1152\/ajpregu.00268.2014","article-title":"Reduced uterine perfusion pressure induces hypertension in the pregnant mouse","volume":"307","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0109","doi-asserted-by":"crossref","first-page":"e0155426","DOI":"10.1371\/journal.pone.0155426","article-title":"Reduced Uterine Perfusion Pressure (RUPP) Model of preeclampsia in mice","volume":"11","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171009051724_CIT0110","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","year":"2003","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171009051724_CIT0111","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1582-4934.2009.00820.x","article-title":"Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model","volume":"14","year":"2010","journal-title":"J Cell Mol Med"},{"key":"key\n\t\t\t\t20171009051724_CIT0112","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/ajh.2009.24","article-title":"Oxidative stress contributes to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant rats","volume":"22","year":"2009","journal-title":"Am J Hypertens"},{"key":"key\n\t\t\t\t20171009051724_CIT0113","doi-asserted-by":"crossref","first-page":"R259","DOI":"10.1152\/ajpregu.00319.2011","article-title":"L-arginine supplementation abolishes the blood pressure and endothelin response to chronic increases in plasma sFlt-1 in pregnant rats","volume":"302","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0114","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1172\/JCI83918","article-title":"Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia","volume":"126","year":"2016","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171009051724_CIT0115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1681\/ASN.2013030291","article-title":"Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor","volume":"25","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20171009051724_CIT0116","doi-asserted-by":"crossref","first-page":"H189","DOI":"10.1152\/ajpheart.00792.2009","article-title":"Long-term maternal cardiovascular function in a mouse model of sFlt-1-induced preeclampsia","volume":"298","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171009051724_CIT0117","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/HYPERTENSIONAHA.114.04971","article-title":"Exposure to experimental preeclampsia in mice enhances the vascular response to future injury","volume":"65","year":"2015","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171009051724_CIT0118","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1152\/physiolgenomics.00125.2015","article-title":"Preeclampsia, of mice and women","volume":"48","year":"2016","journal-title":"Physiol Genomics"},{"key":"key\n\t\t\t\t20171009051724_CIT0119","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0002-9378(00)24793-5","article-title":"Association of preeclampsia with high birth weight for age","volume":"183","year":"2000","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajh\/article-pdf\/30\/11\/1053\/20725927\/hpx063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T05:25:18Z","timestamp":1719120318000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/ajh\/article\/30\/11\/1053\/3787770\/New-Models-of-PregnancyAssociated-Hypertension"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":119,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,5,2]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpx063","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11]]},"published":{"date-parts":[[2017,5,2]]}}}