{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:33:55Z","timestamp":1790357635728,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P20RR011104"],"award-info":[{"award-number":["P20RR011104"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Electrocardiographic (ECG) left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular (CV) morbidity and mortality. However, the predictive value of ECG LVH in treated hypertensive patients remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 33,357 patients (aged \u2265 55 years) with hypertension and at least 1 other coronary heart disease (CHD) risk factor were randomized to chlorthalidone, amlodipine, or lisinopril. The outcome of the present study was all-cause mortality; and secondary endpoints were CHD, nonfatal myocardial infarction (MI), stroke, angina, heart failure (HF), and peripheral arterial disease. Cornell voltage criteria (S in V3 + R in aVL &amp;gt; 28 [men] or &amp;gt;22 mm [women]) defined ECG LVH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>ECGs were available at baseline in 26,384 patients. Baseline Cornell voltage LVH was present in 1,741 (7%) patients, who were older (67.4 vs. 66.6 years, P &amp;lt; 0.001), more likely to be female (74 vs. 44%, P &amp;lt; 0001) with a higher systolic blood pressure (151 vs. 146 mm Hg, P &amp;lt; 0.001) than patients without ECG LVH. During 5.0 \u00b1 1.4 years mean follow-up, baseline and in-study ECG LVH was significantly associated with 29 to 98% increased risks of all-cause mortality, MI, CHD, stroke, and HF in multivariable Cox analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Baseline Cornell voltage LVH is associated with increased CV morbidity and all-cause mortality in treated hypertensive patients independent of treatment modality and other CV risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIALS REGISTRATION<\/jats:title>\n                    <jats:p>Trial Number NCT00000542.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpx067","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T23:13:38Z","timestamp":1491002018000},"page":"914-922","source":"Crossref","is-referenced-by-count":62,"title":["Electrocardiographic Left Ventricular Hypertrophy Predicts Cardiovascular Morbidity and Mortality in Hypertensive Patients: The ALLHAT Study"],"prefix":"10.1093","volume":"30","author":[{"given":"Casper N","family":"Bang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Weill Cornell Medical College 1 , New York, New York , USA ;"},{"name":"Department of Cardiology, Zealand University Hospital Roskilde 2 , Roskilde , Denmark ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed Z","family":"Soliman","sequence":"additional","affiliation":[{"name":"Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Section of Cardiology, Department of Medicine, Wake Forest School of Medicine 3 , Winston Salem, North Carolina , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics|Coordinating Center for Clinical Trials, School of Public Health, The University of Texas Health Science Center at Houston 4 , Houston, Texas , USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry R","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics|Coordinating Center for Clinical Trials, School of Public Health, The University of Texas Health Science Center at Houston 4 , Houston, Texas , USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B","family":"Devereux","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Weill Cornell Medical College 1 , New York, New York , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Okin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Weill Cornell Medical College 1 , New York, New York , USA ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and for the ALLHAT Collaborative Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"2022111818053001600_CIT0001","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N Engl J Med"},{"key":"2022111818053001600_CIT0002","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1161\/01.CIR.90.4.1786","article-title":"Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy","volume":"90","author":"Levy","year":"1994","journal-title":"Circulation"},{"key":"2022111818053001600_CIT0003","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0895-7061(97)88956-X","article-title":"The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study: rationale, design, and methods. 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