{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:55:24Z","timestamp":1776214524847,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM104932"],"award-info":[{"award-number":["P20GM104932"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["GRNT31460000"],"award-info":[{"award-number":["GRNT31460000"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Preeclampsia is a pregnancy complication which manifests as new-onset hypertension, proteinuria, and a spectrum of other symptoms. While the underlying causes are still a subject of much debate, it is commonly believed that placental ischemia is a central cause. The ischemic placenta secretes factors which are believed to be responsible for the maternal syndrome; most notably the anti-angiogenic protein soluble fms-like tyrosine kinase 1 (sFlt-1). We have reported that induction of the carbon monoxide (CO) producing protein heme oxygenase-1 restored angiogenic imbalance and reduced blood pressure in a rat model of placental ischemia, and that CO blocks hypoxia-induced sFlt-1 production from placental tissue in vitro. We therefore hypothesized that direct administration of CO by a CO-releasing molecule (CORM) would blunt the placental ischemia-induced increase in sFlt-1 and thus the hypertension characteristic of this model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We administered a soluble CO donor molecule (CORM-3) daily i.v. in control animals or those undergoing placental ischemia from GD14. Blood pressure and renal function were measured on GD19, and angiogenic markers measured by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Interestingly, though we found that CORM administration significantly blunted the hypertensive response to placental ischemia, there was no concomitant normalization of sFlt-1 in either the placenta or maternal circulation. We did find, however, that CORM administration caused a significant increase in glomerular filtration rate, presumably by vasodilation of the renal arteries and increased renal plasma flow.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>All in all these data suggest that administration of CO by CORMs do lower blood pressure during placental ischemia mechanisms independent of changes in angiogenic balance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpx070","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T15:55:07Z","timestamp":1490975707000},"page":"931-937","source":"Crossref","is-referenced-by-count":19,"title":["Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension"],"prefix":"10.1093","volume":"30","author":[{"given":"Eric M","family":"George","sequence":"first","affiliation":[{"name":"Departments of Physiology and Biophysics, University of Mississippi Medical Center 1 , Jackson, Mississippi , ;","place":["USA"]},{"name":"Department of Biochemistry, University of Mississippi Medical Center 2 , Jackson, Mississippi , ;","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Cockrell","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, University of Mississippi Medical Center 1 , Jackson, Mississippi , ;","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marietta","family":"Arany","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, University of Mississippi Medical Center 1 , Jackson, Mississippi , ;","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Stec","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, University of Mississippi Medical Center 1 , Jackson, Mississippi , ;","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Rimoldi","sequence":"additional","affiliation":[{"name":"Department of BioMolecular Sciences, The University of Mississippi 3 , University, Mississippi , .","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama SV","family":"Gadepalli","sequence":"additional","affiliation":[{"name":"Department of BioMolecular Sciences, The University of Mississippi 3 , University, Mississippi , .","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joey P","family":"Granger","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics, University of Mississippi Medical Center 1 , Jackson, Mississippi , ;","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"2026041420044655100_CIT0001","first-page":"1122","article-title":"Hypertension in pregnancy. 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