{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T23:01:59Z","timestamp":1754262119504},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Coronary artery calcification (CAC) is associated with increased cardiovascular (CV) risk. Left ventricular hypertrophy (LVH) is an independent risk factor for CV events. Our aim was to estimate the relative CV risk of LVH in the presence of CAC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We included asymptomatic hypertensive patients who were enrolled in the calcification arm of the INSIGHT (International Nifedipine Study Intervention as Goal for Hypertension Therapy). Patients had baseline echocardiography and computed tomography to assess CAC. The primary end-point was the first CV event.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Two hundred and fifty-two subjects (mean age 64.7 \u00b1 5.5 years, 54% men) were followed for a mean of 13.3 \u00b1 2.6 years. 72 patients (28.5%) had LVH and 159 patients (63%) had CAC. During follow up, 89 patients had a first CV event. The rate of CV events was higher in those with than in those without CAC (43.4% vs. 21.5%, P &amp;lt; 0.01) and in those with than in those without LVH (44% vs. 31.6%, P &amp;lt; 0.01). However, LVH had no effect on CV events in the absence of CAC, whereas LVH almost doubled the rate of CV events (61.4% vs. 36.5%, P &amp;lt; 0.01) in the presence of CAC. In comparison to patients without CAC and without LVH the hazard ratio for CV event in those with LVH was 1.46 (95% confidence interval [CI], 0.50\u20134.21) in those without CAC and 4.4 (95% CI, 2.02\u20139.56) in those with CAC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>LVH and CAC independently predict CV events in asymptomatic hypertensive patients. However, the risk of LVH is mainly observed in those with CAC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpx181","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T03:08:03Z","timestamp":1507000083000},"page":"313-320","source":"Crossref","is-referenced-by-count":13,"title":["Left Ventricular Hypertrophy Predicts Cardiovascular Events in Hypertensive Patients With Coronary Artery Calcifications"],"prefix":"10.1093","volume":"31","author":[{"given":"Chagai","family":"Grossman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine F and the Rheumatology unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Levin","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Grace Ballas Research Unit of the Cardiac Rehabilitation Institute, Sackler Faculty of Medicine, Tel-Aviv University, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nira","family":"Koren-Morag","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Department of Epidemiology and Preventive Medicine, The Chaim Sheba Medical Center, Tel-Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gill","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Department of Internal Medicine D and hypertension unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avshalom","family":"Leibowitz","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Department of Internal Medicine D and hypertension unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Ben-Zvi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F and the Rheumatology unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Shemesh","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Grace Ballas Research Unit of the Cardiac Rehabilitation Institute, Sackler Faculty of Medicine, Tel-Aviv University, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Grossman","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Department of Internal Medicine D and hypertension unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"2022111502390730500_CIT0001","first-page":"e28","article-title":"Heart disease and stroke statistics\u20132014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"2022111502390730500_CIT0002","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/01.CIR.90.1.583","article-title":"Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. 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