{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:01:13Z","timestamp":1779188473374,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373076"],"award-info":[{"award-number":["81373076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Natural Science Foundation","award":["7172023"],"award-info":[{"award-number":["7172023"]}]},{"name":"National Key Research and Development Program of China","award":["2016YFC0900603"],"award-info":[{"award-number":["2016YFC0900603"]}]},{"name":"Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions","award":["CIT&TCD201504088"],"award-info":[{"award-number":["CIT&TCD201504088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential hypertension as well as being an independent risk factor for cardiovascular disease. However, effective medications for the treatment of SSH have not been clarified. This study was to compare the efficacious of different classes of antihypertensive agents combined with salt intake on the reduction of blood pressure (BP) in patients with SSH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We used sources as PubMed, EMBASE, Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), CNKI, and WANFANG database from inception to November 2016. Studies that compared the efficacy of 2 or more antihypertensive agents or placebos in adult salt-sensitive hypertensive patients were included. The outcomes included variations in mean arterial blood pressure, systolic and diastolic blood pressure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Twenty-five studies were involved in this meta-analysis. A calcium channel blocker (CCB) with hydrochlorothiazide and moderate salt intake was significantly the most efficacious in comparison with placebo (standardized mean differences (SMD), 95% credibility intervals (CI): 26.66, 12.60 to 40.16), angiotensin receptor blockers (ARBs) (SMD, 95% CI: 22.94, 5.26 to 40.51), and the other interventions for patients with SSH and no concomitant diseases. For SSH patients who were obese, CCB with metformin and moderate salt intake would decrease blood pressure with 17.90 mm Hg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>For SSH patients with no concomitant diseases, CCB combined with hydrochlorothiazide and moderate salt intake was optimal in reducing BP, while CCB combined with metformin and moderate salt intake was the most efficacious at reducing BP in SSH patients with coexisting obesity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpy027","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T12:09:11Z","timestamp":1518091751000},"page":"835-846","source":"Crossref","is-referenced-by-count":19,"title":["Comparative Efficacy of Antihypertensive Agents in Salt-Sensitive Hypertensive Patients: A Network Meta-Analysis"],"prefix":"10.1093","volume":"31","author":[{"given":"Han","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"},{"name":"Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Juan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Jie","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Arthropathy, Yantai Yantaishan Hospital, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tao","family":"Xiang","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"2022101807014955100_CIT0001","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.55.5.779","article-title":"Natriuretic response to saline infusion in normotensive and hypertensive man. The role of renin suppression in exaggerated natriuresis","volume":"55","author":"Luft","year":"1977","journal-title":"Circulation"},{"key":"2022101807014955100_CIT0002","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9343(78)90045-1","article-title":"The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension","volume":"64","author":"Kawasaki","year":"1978","journal-title":"Am J Med"},{"key":"2022101807014955100_CIT0003","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/01.HYP.37.2.429","article-title":"Salt sensitivity, pulse pressure, and death in normal and hypertensive humans","volume":"37","author":"Weinberger","year":"2001","journal-title":"Hypertension"},{"key":"2022101807014955100_CIT0004","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1523-1755.2004.00389.x","article-title":"Sodium glomerulopathy: tubuloglomerular feedback and renal injury in African Americans","volume":"65","author":"Aviv","year":"2004","journal-title":"Kidney Int"},{"key":"2022101807014955100_CIT0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"2022101807014955100_CIT0006","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/hy1201.096569","article-title":"Omapatrilat versus lisinopril: efficacy and neurohormonal profile in salt-sensitive hypertensive patients","volume":"38","author":"Campese","year":"2001","journal-title":"Hypertension"},{"key":"2022101807014955100_CIT0007","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00005344-199909000-00005","article-title":"Acute hypotensive, natriuretic, and hormonal effects of nifedipine in salt-sensitive and salt-resistant black normotensive and hypertensive subjects","volume":"34","author":"Damasceno","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"2022101807014955100_CIT0008","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/bmj.331.7521.897","article-title":"Simultaneous comparison of multiple treatments: combining direct and indirect evidence","volume":"331","author":"Caldwell","year":"2005","journal-title":"BMJ"},{"key":"2022101807014955100_CIT0009","first-page":"CD004022","article-title":"Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride","author":"Graudal","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"2022101807014955100_CIT0010","volume-title":"A Cochrane Risk of Bias Assessment Tool for Non-Randomized Studies of Interventions (ACROBAT-NRSI)","author":"Sterne","year":"2014"},{"key":"2022101807014955100_CIT0011","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Higgins","year":"2011"},{"key":"2022101807014955100_CIT0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00019053-200624010-00001","article-title":"Bayesian methods for evidence synthesis in cost-effectiveness analysis","volume":"24","author":"Ades","year":"2006","journal-title":"Pharmacoeconomics"},{"key":"2022101807014955100_CIT0013","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/0272989X12458724","article-title":"Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials","volume":"33","author":"Dias","year":"2013","journal-title":"Med Decis Making"},{"key":"2022101807014955100_CIT0014","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/sim.3767","article-title":"Checking consistency in mixed treatment comparison meta-analysis","volume":"29","author":"Dias","year":"2010","journal-title":"Stat Med"},{"key":"2022101807014955100_CIT0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial","volume":"64","author":"Salanti","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"2022101807014955100_CIT0016","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/00005344-199604000-00018","article-title":"Antihypertensive and renal effects of acute and chronic therapy with a dihydropyridine Ca-antagonist in patients with different salt sensitivity","volume":"27","author":"Galletti","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"2022101807014955100_CIT0017","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7326\/0003-4819-107-2-329","article-title":"The antihypertensive effect of verapamil at extremes of dietary sodium intake","volume":"107","author":"Nicholson","year":"1987","journal-title":"Ann Intern Med"},{"key":"2022101807014955100_CIT0018","first-page":"141","article-title":"[Clinical effect of levamlodipine besylate combined with metformin on mild to moderate salt-sensitive obesity induced hypertension]","volume":"23","author":"Dong","year":"2015","journal-title":"Pract J Cardiac Cerebr Pneum Vasc Dis"},{"key":"2022101807014955100_CIT0019","first-page":"372","article-title":"Determination of plasma atrial natriuretic peptide, angiotensin II, aldosterone and efficacy of benazepril in patients with salt sensitive essential hypertension [Chinese]","volume":"27","author":"Huang","year":"1999","journal-title":"Chin J Cardiol"},{"key":"2022101807014955100_CIT0020","first-page":"149","article-title":"[The effect of Amlodipine in treatment of hypertensive patients with salt sensitivity]","volume":"8","author":"Wang","year":"2013","journal-title":"China Prac Med"},{"key":"2022101807014955100_CIT0021","first-page":"89","article-title":"[The effect of levamlodipine besylate combined with metformin on mild to moderate salt-sensitive obesity induced hypertension]","volume":"16","year":"2016","journal-title":"World Latest Med Inform"},{"key":"2022101807014955100_CIT0022","article-title":"[The effects of amlodipine combined with hydrochlorothiazide in treatment of hypertensive patients with salt sensitivity]","volume":"54","author":"Hou","year":"2011","journal-title":"People\u2019s Milit Surg"},{"key":"2022101807014955100_CIT0023","first-page":"251","article-title":"[The effects of amlodipine on ambulatory blood pressure in hypertensive patients with salt sensitivity: a comparison with enalapril]","volume":"7","author":"Liu","year":"1999","journal-title":"Chin J Hypertens"},{"key":"2022101807014955100_CIT0024","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0895-7061(00)01183-3","article-title":"Effects of isradipine or enalapril on blood pressure in salt-sensitive hypertensives during low and high dietary salt intake. MIST II Trial Investigators","volume":"13","author":"Chrysant","year":"2000","journal-title":"Am J Hypertens"},{"key":"2022101807014955100_CIT0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0895-7061(02)02268-9","article-title":"Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension","volume":"15","author":"Ferrario","year":"2002","journal-title":"Am J Hypertens"},{"key":"2022101807014955100_CIT0026","first-page":"2711","article-title":"[Hydrochlorothiazide in treatment of primary hypertensive patients with salt sensitivity]","volume":"17","author":"Tian","year":"2013","journal-title":"Med Forums Basic"},{"key":"2022101807014955100_CIT0027","first-page":"1540","article-title":"[Influence of sodium chloride to curative effect of captopril in treatment of salt-sensitive hypertension]","volume":"16","author":"Long Juhua","year":"2006","journal-title":"China J Modern Med"},{"key":"2022101807014955100_CIT0028","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00005344-200307000-00015","article-title":"Influence of two doses of irbesartan on non-dipper circadian blood pressure rhythm in salt-sensitive black hypertensives under high salt diet","volume":"42","author":"Pol\u00f3nia","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"2022101807014955100_CIT0029","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1172\/JCI117445","article-title":"Intracellular ionic consequences of dietary salt loading in essential hypertension. Relation to blood pressure and effects of calcium channel blockade","volume":"94","author":"Resnick","year":"1994","journal-title":"J Clin Invest"},{"key":"2022101807014955100_CIT0030","first-page":"1387","article-title":"[Levamlodipine besylate combined with low dose hydrochlorothiazide in treatment of primary hypertensive patients with salt sensitivity: analysis of curative efficacy]","volume":"24","author":"Hou","year":"2011","journal-title":"J Med Theor &Prac"},{"key":"2022101807014955100_CIT0031","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.HYP.11.6.703","article-title":"Role of cellular calcium in salt sensitivity of patients with essential hypertension","volume":"11","author":"Oshima","year":"1988","journal-title":"Hypertension"},{"key":"2022101807014955100_CIT0032","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/01.HYP.30.3.422","article-title":"Salt and blood pressure responses to calcium antagonism in hypertensive patients","volume":"30","author":"Weir","year":"1997","journal-title":"Hypertension"},{"key":"2022101807014955100_CIT0033","first-page":"379","article-title":"Salt sensitivity in human essential hypertension: effect of renin-angiotensin and sympathetic nervous system blockade","volume":"11","author":"Dichtchekenian","year":"1989","journal-title":"Clin Exp Hypertens A"},{"key":"2022101807014955100_CIT0034","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0895-7061(95)00300-2","article-title":"Salt sensitivity of hypertension and responses to angiotensin converting enzyme inhibition with benazepril","volume":"9","author":"Moore","year":"1996","journal-title":"Am J Hypertens"},{"key":"2022101807014955100_CIT0035","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1097\/HJH.0b013e328312677e","article-title":"Telmisartan improves insulin resistance in high renin nonmodulating salt-sensitive hypertensives","volume":"26","author":"Sanchez","year":"2008","journal-title":"J Hypertens"},{"key":"2022101807014955100_CIT0036","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ki.1995.20","article-title":"Vascular compliance in sodium-sensitive and sodium-resistant borderline hypertensive patients","volume":"47","author":"Draaijer","year":"1995","journal-title":"Kidney Int"},{"key":"2022101807014955100_CIT0037","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1161\/HYP.0000000000000047","article-title":"Salt sensitivity of blood pressure: a scientific statement from the American Heart Association","volume":"68","author":"Elijovich","year":"2016","journal-title":"Hypertension"},{"key":"2022101807014955100_CIT0038","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1253\/jcj.49.984","article-title":"Abnormal renal hemodynamics in salt-sensitive patients with essential hypertension","volume":"49","author":"Ando","year":"1985","journal-title":"Jpn Circ J"},{"key":"2022101807014955100_CIT0039","doi-asserted-by":"crossref","first-page":"171A","DOI":"10.1016\/S0895-7061(02)02738-3","article-title":"Renal hemodynamics and natriuresis in hypertensive patients with salt sensitivity","volume":"15","author":"Liu","year":"2002","journal-title":"Am J Hypertens"},{"key":"2022101807014955100_CIT0040","doi-asserted-by":"crossref","first-page":"C165","DOI":"10.1152\/ajpcell.1977.232.5.C165","article-title":"Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis","volume":"232","author":"Blaustein","year":"1977","journal-title":"Am J Physiol"},{"key":"2022101807014955100_CIT0041","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jsbmb.2014.08.012","article-title":"Voltage-gated calcium channels in the human adrenal and primary aldosteronism","volume":"144","author":"Felizola","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2022101807014955100_CIT0042","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/01.HYP.0000086521.95630.5A","article-title":"Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)","volume":"42","author":"Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group.","year":"2003","journal-title":"Hypertension (Dallas, Tex.: 1979)"},{"key":"2022101807014955100_CIT0043","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","article-title":"Inflammation and insulin resistance","volume":"582","author":"de Luca","year":"2008","journal-title":"FEBS Lett"},{"key":"2022101807014955100_CIT0044","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3945\/ajcn.2009.29028","article-title":"Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension","volume":"92","author":"Yatabe","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"2022101807014955100_CIT0045","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2165\/00003495-199549050-00007","article-title":"Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus","volume":"49","author":"Dunn","year":"1995","journal-title":"Drugs"},{"key":"2022101807014955100_CIT0046","first-page":"CD003654","article-title":"Calcium channel blockers versus other classes of drugs for hypertension","author":"Chen","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"2022101807014955100_CIT0047","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0895-7061(01)02204-X","article-title":"Role of angiotensin converting enzyme genotype in sodium sensitivity in older hypertensives","volume":"14","author":"Dengel","year":"2001","journal-title":"Am J Hypertens"},{"key":"2022101807014955100_CIT0048","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1056\/NEJM200101043440101","article-title":"Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group","volume":"344","author":"Sacks","year":"2001","journal-title":"N Engl J Med"},{"key":"2022101807014955100_CIT0049","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1631\/jzus.B1600341","article-title":"Dietary guidelines for chinese residents (2016): comments and comparisons","volume":"17","author":"Wang","year":"2016","journal-title":"J Zhejiang Univ Sci B"},{"key":"2022101807014955100_CIT0050","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.HYP.0000202568.01167.B6","article-title":"Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association","volume":"47","author":"Appel","year":"2006","journal-title":"Hypertension"},{"key":"2022101807014955100_CIT0051","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/jama.2015.18359","article-title":"Ushering hypertension into a new era of precision medicine","volume":"315","author":"Kotchen","year":"2016","journal-title":"JAMA"},{"key":"2022101807014955100_CIT0052","volume-title":"Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease","author":"National Research Council (US) Committee on A Framework for Developing a New Taxonomy of Disease","year":"2011"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/31\/7\/835\/46548418\/ajh_31_7_835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/31\/7\/835\/46548418\/ajh_31_7_835.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T07:03:01Z","timestamp":1666076581000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/31\/7\/835\/4846349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,2,9]]},"published-print":{"date-parts":[[2018,6,11]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpy027","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,2,9]]}}}