{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:26:57Z","timestamp":1740119217922,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T00:00:00Z","timestamp":1527638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma K.K","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>We aimed to assess the association of changes in brachial or central nocturnal systolic blood pressure (SBP) with change in urine albumin\u2013creatinine ratio (UACR) by a valsartan\/amlodipine combination (80\/5 mg) therapy in hypertensive patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Twenty-three patients (age range, 47\u201378 years; mean, 68.0 years; 35% men, 65% with chronic kidney disease) with clinic brachial BP \u2265140\/90 mm Hg were treated with valsartan\/amlodipine combination therapy for 16 weeks. At baseline and 16 weeks later, we measured brachial and central nocturnal SBP using an oscillometric Mobil-O-Graph device and UACR by spot urine in 23 patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The changes in brachial nocturnal SBP (r = 0.445, P = 0.033) and those in central nocturnal SBP (r = 0.616, P = 0.002) were significantly associated with change in UACR by intervention. In multivariable-adjusted multiple regression analyses including changes in both brachial and central nocturnal SBP jointly, only central nocturnal SBP change retained a statistically significant association with change in UACR (\u03b2 = 0.919, P = 0.020).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Lowering central nocturnal SBP by a valsartan\/amlodipine combination therapy was associated with reduction of UACR, independently of brachial nocturnal SBP reduction. Central nocturnal SBP may be a therapeutic target to protect the kidney. A larger scale interventional study will be needed to confirm the kidney protection conferred by lowering central nocturnal SBP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL TRIALS REGISTRATION<\/jats:title>\n                  <jats:p>Trial Number UMIN000013519.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpy078","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T11:08:03Z","timestamp":1527073683000},"page":"995-1001","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Change in Central Nocturnal Blood Pressure and Urine Albumin\u2013Creatinine Ratio by a Valsartan\/Amlodipine Combination: A CPET Study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-2806","authenticated-orcid":false,"given":"Takeshi","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan"},{"name":"Higashiagatsuma-machi National Health Insurance Clinic, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5751","authenticated-orcid":false,"given":"Satoshi","family":"Hoshide","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kanegae","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan"},{"name":"Genki Plaza Medical Center for Health Care, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Medical Center, Miyagi University of Education, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"2022101717063263700_CIT0001","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/01.CIR.95.7.1827","article-title":"Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. 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