{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:57:58Z","timestamp":1778126278333,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Although increasing evidence has suggested the significant association between dysglycemia and hypertension, this association is less well described in prediabetes. Additionally, it is unclear how risk of hypertension varies according to the change of glycemic state.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Five thousand four hundred thirteen nondiabetic Koreans were dichotomized into normoglycemia (NG) and prediabetes group and followed-up for 10 years. Cox proportional hazard model was used to evaluate hazard ratios (HRs) with 95% confidence interval (CI) [adjusted HRs (95% CI)] for the development of hypertension. Subgroup analysis was conducted in subdivided glycated hemoglobin (HbA1c) with &amp;lt;5.7%, 5.7\u20135.9%, and 6.0\u20136.4% and 2 hour post-load glucose (2 hr-PG) with &amp;lt;140, 140\u2013169, and 170\u2013199 mg\/dl. The glycemic states are NG, prediabetes, and diabetes mellitus (DM), which are used in evaluating the change of glycemic state during follow-up in baseline NG (NG \u2192 NG, NG \u2192 prediabetes, and NG \u2192 DM) and baseline prediabetes (prediabetes \u2192 prediabetes and prediabetes \u2192 DM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Compared with NG, prediabetes was not significantly associated with the risk of hypertension [1.11 (0.997\u20131.23)]. HbA1c \u22655.7% [1.13 (1.02\u20131.26)] and 2 hr-PG \u2265140 mg\/dl [1.15 (1.004\u20131.31)] were marginally associated with the risk of hypertension. In subgroup analysis, only 2 hr-PG of 170\u2013199 mg\/dl showed the significantly increased risk of hypertension [1.37 (1.09\u20131.73)]. Compared with the maintaining glycemic state, the progression of glycemic state had the significantly increased risk of hypertension [NG \u2192 prediabetes; 1.41 (1.19\u20131.67), NG\u2192DM; 1.77 (1.36\u20132.30), and prediabetes \u2192 DM; 1.32 (1.13\u20131.55)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>The progression of glycemic state was a strong determinant on the development of hypertension.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpy094","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T19:44:11Z","timestamp":1529523851000},"page":"1042-1048","source":"Crossref","is-referenced-by-count":15,"title":["Long-Term Risk of Hypertension in Normoglycemia and Prediabetes, and Their Relation to the Change of Glycemic State"],"prefix":"10.1093","volume":"31","author":[{"given":"Ju Young","family":"Jung","sequence":"first","affiliation":[{"name":"Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Mo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong-Myung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hong","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, College of Medicine, Kyung Hee University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4703-9917","authenticated-orcid":false,"given":"Sung Keun","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"2022101717063725100_CIT0001","doi-asserted-by":"crossref","first-page":"3B","DOI":"10.1016\/j.amjcard.2011.03.013","article-title":"Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose","volume":"108","author":"DeFronzo","year":"2011","journal-title":"Am J Cardiol"},{"key":"2022101717063725100_CIT0002","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc16-S005","article-title":"Standards of medical care 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