{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:37:08Z","timestamp":1767915428495,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL110957"],"award-info":[{"award-number":["R01HL110957"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The relationship between pediatric severe obesity (SO) and central aortic blood pressure (BP) has yet to be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We conducted a cross-sectional study of 348 youth (48.5% male, age 12.7 \u00b1 0.1 years) with a wide range of body mass index (BMI) values: normal weight (NW; \u22655th and &amp;lt;85th BMI percentiles), overweight\/obesity (OW\/OB; 85th to &amp;lt;120% of the 95th BMI percentile), and SO (\u2265120% of the 95th BMI percentile). Measures of central aortic BP were obtained via applanation tonometry with SphygmoCor MM3 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After adjustment for covariates, no significant sex differences were observed for radial\u2212aortic systolic blood pressure (SBP) (P = 0.39), carotid\u2212aortic SBP (P = 0.99), radial\u2212aortic diastolic blood pressure (DBP) (P = 0.44), and carotid\u2212aortic DBP (P = 0.53). Compared to youth with NW, youth with SO exhibited higher radial\u2212aortic SBP (SO vs. NW: 102 \u00b1 1 mm Hg vs. 90 \u00b1 1 mm Hg, P&amp;lt;0.001), carotid\u2212aortic SBP (SO vs. NW: 121 \u00b1 1 mm Hg vs. 109 \u00b1 1 mm Hg, P&amp;lt;0.001), and carotid\u2212aortic DBP (SO vs. NW: 60 \u00b1 1 mm Hg vs. 56 \u00b1 1 mm Hg, P = 0.04). Compared to youth with OW\/OB, youth with SO had higher radial\u2212aortic SBP (OW\/OB: 97 \u00b1 1 mm Hg, P = 0.002) and carotid\u2212aortic SBP (OW\/OB: 114 \u00b1 1 mm Hg, P = 0.007). After adjusting for either total-body percent fat mass or visceral adipose tissue, BMI was still a significant predictor of both radial\u2212aortic and carotid\u2212aortic SBP and DBP (P&amp;lt;0.001, all).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In a cohort of youth with a wide range of adiposity levels, central aortic BP was elevated among individuals with SO and associated with BMI but not body fatness.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajh\/hpy128","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T19:12:41Z","timestamp":1533755561000},"page":"1286-1292","source":"Crossref","is-referenced-by-count":18,"title":["Measurement of Central Aortic Blood Pressure in Youth: Role of Obesity and Sex"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-3874","authenticated-orcid":false,"given":"Michelle M","family":"Harbin","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil E","family":"Hultgren","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA"},{"name":"Center for Pediatric Obesity Medicine, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA"},{"name":"Center for Pediatric Obesity Medicine, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R","family":"Dengel","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA"},{"name":"Center for Pediatric Obesity Medicine, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas G","family":"Evanoff","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Center for Pediatric Obesity Medicine, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin R","family":"Ryder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, 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