{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:07:14Z","timestamp":1781118434276,"version":"3.54.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T00:00:00Z","timestamp":1546646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Key Research and Development","award":["2016YFC0903103"],"award-info":[{"award-number":["2016YFC0903103"]}]},{"name":"National Key Research and Development","award":["2016YFC0904900"],"award-info":[{"award-number":["2016YFC0904900"]}]},{"name":"National Key Research and Development","award":["2016YFE0205400"],"award-info":[{"award-number":["2016YFE0205400"]}]},{"name":"National Key Research and Development","award":["2018ZX09739"],"award-info":[{"award-number":["2018ZX09739"]}]},{"name":"National Key Research and Development","award":["2018ZX 09301034003"],"award-info":[{"award-number":["2018ZX 09301034003"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["201707020010"],"award-info":[{"award-number":["201707020010"]}]},{"name":"Science, Technology and Innovation Committee of Shenzhen","award":["JSGG20170412155639040"],"award-info":[{"award-number":["JSGG20170412155639040"]}]},{"name":"Science, Technology and Innovation Committee of Shenzhen","award":["GJHS20170314114526143"],"award-info":[{"award-number":["GJHS20170314114526143"]}]},{"name":"President Foundation of Nanfang Hospital, Southern Medical University","award":["2017C007"],"award-info":[{"award-number":["2017C007"]}]},{"name":"Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University","award":["2017J009"],"award-info":[{"award-number":["2017J009"]}]},{"DOI":"10.13039\/501100001809","name":"Projects of National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81473052"],"award-info":[{"award-number":["81473052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Project of Guangdong Province","award":["2014B090904040"],"award-info":[{"award-number":["2014B090904040"]}]},{"name":"Projects of National Science Foundation","award":["81402735"],"award-info":[{"award-number":["81402735"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>We aim to evaluate the effect of different lipids parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), the TG to HDL-C (TG:HDL-C) ratio, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), on the risk of rapid renal function decline and examine any possible effect modifiers in general hypertensive patients with normal renal function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A total of 12,549 hypertensive patients with estimated glomerular filtration rate (eGFR) \u226560 ml\/min\/1.73 m2 in the renal sub-study of the China Stroke Primary Prevention Trial were included in the analyses. The primary outcome was rapid renal function decline, defined as an average decline in eGFR \u2265 5 ml\/min\/1.73 m2 per year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The median treatment duration was 4.4 years. After the full adjustment for TC, TG, HDL-C, and other major covariates, a significantly higher risk of rapid renal function decline was found in participants with higher TG [\u2265150 vs. &amp;lt;150 mg\/dl, 7.7% vs. 5.5%; odds ratios (OR): 1.27; 95% confidence interval (CI): 1.06\u20131.51], higher TG:HDL-C ratio [\u22652.7 (median) vs. &amp;lt;2.7, 7.7% vs. 5.0%; OR: 1.39; 95% CI: 1.14\u20131.71), lower TC (\u2265200 vs. &amp;lt;200 mg\/dl, 6.0% vs. 7.0%; OR: 0.79; 95% CI: 0.67\u20130.93), or lower LDL-C levels (\u2265130 vs. &amp;lt;130 mg\/dl, 6.1% vs. 7.0%; OR: 0.79; 95% CI: 0.67\u20130.94). Moreover, the increased risk of the primary outcome associated with elevated TG was particularly evident among individuals with lower total homocysteine levels [&amp;lt;12.4 (median) vs. \u2265 12.4 \u03bcmol\/l, P interaction = 0.036].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Higher TG and TG:HDL-C ratio were independent risk factors for rapid renal function decline in hypertensive adults with normal renal function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz001","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T20:10:42Z","timestamp":1546546242000},"page":"393-401","source":"Crossref","is-referenced-by-count":11,"title":["Serum Lipids and Risk of Rapid Renal Function Decline in Treated Hypertensive Adults With Normal Renal 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