{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:27:02Z","timestamp":1740119222022,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Our objective of this study was to determine if rate of estimated glomerular filtration rate (eGFR) decline and its intensity was associated with cardiovascular risk and death in patients with hypertension whose baseline eGFR was higher than 60 ml\/minute\/1.73 m2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This study comprised 2,516 patients with hypertension who had had at least 2 serum creatinine measurements over a 4-year period. An eGFR reduction of \u226510% per year has been deemed as high eGFR and a reduction in eGFR of less than 10% per year as a low decline. The end points were coronary artery disease, stroke, transitory ischemic accident, peripheral arterial disease, heart failure, atrial fibrillation, and death from any cause. Cox regression analyses adjusted for potentially confounding factors were conducted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 2,354 patients with low rate of eGFR decline and 149 with high rate of eGFR decline were analyzed. The adjusted model shows that a \u221210% rate of eGFR decline per year is associated with a higher risk of the primary end point (HR 1.9; 95% CI 1.1\u20133.5; P = 0.02) and arteriosclerotic vascular disease (HR 2.2; 95% CI 1.2\u20134.2; P &amp;lt; 0.001) in all hypertensive groups. The variables associated to high\/low rate of eGFR decline in the logistic regression model were serum creatinine (OR 3.35; P &amp;lt; 0.001), gender, women (OR 15.3; P &amp;lt; 0.001), tobacco user (OR 1.9; P &amp;lt; 0.002), and pulse pressure (OR 0.99; P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A rate of eGFR decline equal to or higher than \u221210% per year is a marker of cardiovascular risk for patients with arterial hypertension without chronic kidney disease at baseline. It may be useful to consider intensifying the global risk approach for these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz029","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T21:01:00Z","timestamp":1550696460000},"page":"890-899","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of the Estimated Glomerular Filtration Rate Decline in Hypertensive Patients Without Chronic Kidney Disease"],"prefix":"10.1093","volume":"32","author":[{"given":"Gabriel","family":"Coll-de-Tuero","sequence":"first","affiliation":[{"name":"MEHTARISC Group, Unitat de Suport a la Recerca Girona, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"},{"name":"Department of Medical Sciences, University of Girona, Girona, Spain"},{"name":"CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Comas-Cuf\u00ed","sequence":"additional","affiliation":[{"name":"MEHTARISC Group, Unitat de Suport a la Recerca Girona, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rodr\u00edguez-Poncelas","sequence":"additional","affiliation":[{"name":"MEHTARISC Group, Unitat de Suport a la Recerca Girona, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Barrot-de-la Puente","sequence":"additional","affiliation":[{"name":"MEHTARISC Group, Unitat de Suport a la Recerca Girona, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Blanch","sequence":"additional","affiliation":[{"name":"MEHTARISC Group, Unitat de Suport a la Recerca Girona, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Figa-Vaello","sequence":"additional","affiliation":[{"name":"MEHTARISC Group, Unitat de Suport a la Recerca Girona, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain"},{"name":"Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-0157","authenticated-orcid":false,"given":"Marc","family":"Saez","sequence":"additional","affiliation":[{"name":"CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain"},{"name":"Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"2022110718085991200_CIT0001","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1681\/ASN.2005040384","article-title":"Kidney function as a predictor of noncardiovascular mortality","volume":"16","author":"Fried","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2022110718085991200_CIT0002","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J Med"},{"key":"2022110718085991200_CIT0003","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0272-6386(03)00916-8","article-title":"A population-based study of the incidence and outcomes of diagnosed chronic kidney disease","volume":"42","author":"Drey","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"2022110718085991200_CIT0004","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1681\/ASN.2007040422","article-title":"Age affects outcomes in chronic kidney disease","volume":"18","author":"O\u2019Hare","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"2022110718085991200_CIT0005","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ki.2010.536","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. 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