{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:27:01Z","timestamp":1740119221612,"version":"3.37.3"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Familial hypercholesterolemia (FH) is a common hereditary lipid disorder associated with substantial risk of premature atherosclerotic cardiovascular disease. We report an interesting newly diagnosed index case of FH in a 31-year-old man who presented to the hospital with an ST-elevated myocardial infarction. He had a background of inadequately treated hypertension and hypercholesterolemia. Further investigations raised the possibility of secondary hypertension after the identification of renal artery stenosis, in addition to other areas of mesenteric arterial stenoses. Our patient\u2019s case highlights that early-onset hypertension and hypercholesterolemia in a young individual may be an early manifestation of FH requiring high clinical vigilance and awareness.<\/jats:p>","DOI":"10.1093\/ajh\/hpz037","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T04:46:17Z","timestamp":1552538777000},"page":"730-733","source":"Crossref","is-referenced-by-count":2,"title":["Familial Hypercholesterolemia With Coexisting Renovascular Stenosis and Premature Coronary Artery Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-0386","authenticated-orcid":false,"given":"Ojas H","family":"Mehta","sequence":"first","affiliation":[{"name":"Monash Cardiovascular Research Centre, MonashHEART, Monash Health, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D","family":"Cameron","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, MonashHEART, Monash Health, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Mirzaee","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, MonashHEART, Monash Health, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"2022110815064608300_CIT0001","first-page":"I66","article-title":"Clinical features of familial hypercholesterolemia","volume":"9","author":"Yamamoto","year":"1989","journal-title":"Arteriosclerosis"},{"key":"2022110815064608300_CIT0002","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jacl.2011.03.452","article-title":"Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the national lipid association expert panel on familial hypercholesterolemia","volume":"5","author":"Hopkins","year":"2011","journal-title":"J Clin Lipidol"},{"key":"2022110815064608300_CIT0003","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/jc.2012-1563","article-title":"Familial hypercholesterolemia in the Danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication","volume":"97","author":"Benn","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2022110815064608300_CIT0004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2004-822987","article-title":"Advanced method for the identification of patients with inherited hypercholesterolemia","volume":"4","author":"Defesche","year":"2004","journal-title":"Semin Vasc Med"},{"key":"2022110815064608300_CIT0005","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/heartjnl-2015-308845","article-title":"Cardiovascular risk stratification in familial hypercholesterolaemia","volume":"102","author":"Sharifi","year":"2016","journal-title":"Heart"},{"key":"2022110815064608300_CIT0006","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1399-0004.2009.01356.x","article-title":"Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project","volume":"77","author":"Taylor","year":"2010","journal-title":"Clin Genet"},{"key":"2022110815064608300_CIT0007","doi-asserted-by":"crossref","first-page":"a2423","DOI":"10.1136\/bmj.a2423","article-title":"Efficacy of statins in familial hypercholesterolaemia: a long term cohort study","volume":"337","author":"Versmissen","year":"2008","journal-title":"BMJ"},{"key":"2022110815064608300_CIT0008","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/jama.1972.03200090031005","article-title":"Clinical characteristics of renovascular hypertension","volume":"220","author":"Simon","year":"1972","journal-title":"JAMA"},{"key":"2022110815064608300_CIT0009","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/01.HYP.36.5.808","article-title":"Renin\u2013angiotensin system polymorphisms and coronary events in familial hypercholesterolemia","volume":"36","author":"Wierzbicki","year":"2000","journal-title":"Hypertension"},{"key":"2022110815064608300_CIT0010","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jacl.2016.03.081","article-title":"Assessment of lipid profile in hypertensive and non-hypertensive males: a case control study","volume":"10","author":"Senarathne","year":"2016","journal-title":"J Clin Lipidol"},{"key":"2022110815064608300_CIT0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.HYP.25.2.155","article-title":"Theodore Cooper memorial lecture. 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