{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:02:46Z","timestamp":1792785766287,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["5RO1 NS46259-03"],"award-info":[{"award-number":["5RO1 NS46259-03"]}]},{"DOI":"10.13039\/100008871","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"crossref","award":["5-2002-185"],"award-info":[{"award-number":["5-2002-185"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease-modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with type 1 diabetes mellitus (T1DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Subjects with T1DM (n = 70) and controls (n = 78) underwent a comprehensive assessment of DPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Hypertension was present in 40 of 70 T1DM subjects and 20 of 78 controls. Hypertension was associated with abnormal nerve conduction parameters (P = 0.03 to &lt;0.001), increased vibration perception threshold (P = 0.01) and reduced corneal nerve fiber density and length (P = 0.02) in subjects with T1DM. However, after adjusting for confounding factors only tibial compound motor action potential and nerve conduction velocity were associated with hypertension (P = 0.03) and systolic blood pressure (P &lt; 0.01 to &lt;0.0001). Hypertension had no effect on neuropathy in subjects without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This study shows that hypertension is associated with impaired nerve conduction in T1DM. It supports previous small trials showing that angiotensin-converting enzyme inhibitors improve nerve conduction and advocates the need for larger clinical trials with blood pressure lowering agents in DPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpz058","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T15:20:58Z","timestamp":1555341658000},"page":"796-803","source":"Crossref","is-referenced-by-count":63,"title":["Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes"],"prefix":"10.1093","volume":"32","author":[{"given":"Georgios","family":"Ponirakis","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine\u2013Qatar, Qatar Foundation, Education City, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis N","family":"Petropoulos","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine\u2013Qatar, Qatar Foundation, Education City, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uazman","family":"Alam","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University of Manchester, Manchester, UK"},{"name":"Eye and Vision Sciences, Institute of Ageing and Chronic Disease, University of Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ferdousi","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Asghar","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Marshall","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University of Manchester, Manchester, 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