{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:41:51Z","timestamp":1772005311946,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Research Foundation of Korea funded by the Ministry of Science, ICT, & Future Planning","award":["NRF-2017R1D1A3B03028830"],"award-info":[{"award-number":["NRF-2017R1D1A3B03028830"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endothelial function is an independent predictor of coronary artery disease (CAD) and is regulated by a number of factors, including blood pressure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The current study was designed to test the hypothesis that intra-arterial invasive central blood pressure is strongly associated with endothelial function in patients with CAD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In patient with CAD (diameter stenosis \u226530%), invasive central (aortic) and left peripheral (brachial) blood pressures were determined during transradial coronary angiography. The endothelial function was evaluated by way of flow-mediated dilatation (FMD) of the brachial artery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We enrolled 413 consecutive patients. There were 260 patients with significant CAD (sCAD, diameter stenosis \u226550%) and 153 patients with nonsignificant CAD (nsCAD, diameter stenosis &amp;lt;50% and \u226430%). FMD was significantly and inversely correlated with central and peripheral parameters in terms of systolic blood pressure, mean arterial pressure, and pulse pressure (PP) (r = \u22120.332, r = \u22120.184, and r = \u22120.407, respectively, all P &amp;lt; 0.001) and (r = \u22120.303, r = \u22120.190, and r = \u22120.319, respectively, all P &amp;lt; 0.001). Compared with sCAD, there was closer correlation between central PP with FMD in nsCAD (r = \u22120.548 vs. r = \u22120.345, both P &amp;lt; 0.001). After adjusting potential confounders such as age, body mass index and high-sensitivity C-reactive protein, multivariate analysis showed that FMD remained independently associated with central PP, degree of coronary artery stenosis, and brachial-ankle pulse wave velocity in all patients. In patients with nsCAD, the multivariate analysis showed that only central PP was independently correlated with FMD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with stable CAD, a decline in endothelial function is most closely associated with invasive central pulse pressure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz100","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T11:09:39Z","timestamp":1560856179000},"page":"953-959","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Intra-arterial Invasive Central and Peripheral Blood Pressure and Endothelial Function (Assessed by Flow-Mediated Dilatation) in Stable Coronary Artery Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-8715","authenticated-orcid":false,"given":"Kyoung-Ha","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiovacular Disease, Hallym University Medical Center , Anyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiovacular Disease, Hallym University Medical Center , Anyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Cardiovacular Disease, Hallym University Medical Center , Anyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiovacular Disease, Hallym University Medical Center , Anyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ho","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of Cardiovacular Disease, Hallym University Medical Center , Anyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Ai","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiovacular Disease, Hallym University Medical Center , Anyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Hallym University , Chuncheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"key":"2022101216261338600_CIT0001","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.CIR.0000025404.78001.D8","article-title":"Prognostic value of coronary vascular endothelial 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