{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:55:10Z","timestamp":1790178910909,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The H2FPEF score is recognized as a simple method to diagnose heart failure (HF) with preserved left ventricular ejection fraction (HFpEF). We investigated the value of the H2FPEF score in predicting subsequent cardiovascular events in HFpEF patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study was a retrospective, single-center, observational study. We calculated the H2FPEF scores for 404 consecutive HFpEF patients. Subjects were subdivided into low- (0\u20133), intermediate- (4\u20136), and high-score (7\u20139) groups and followed for 50 months. The primary and secondary endpoints were composite cardiovascular\/cerebrovascular events (cardiovascular death, nonfatal myocardial infarction, unstable angina pectoris, hospitalization for HF decompensation, and nonfatal stroke) occurrence and HF-related events (hospitalization for HF decompensation) occurrence at 50 months, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Kaplan\u2013Meier analyses demonstrated a significantly higher incidence of cardiovascular\/cerebrovascular events among those with a higher H2FPEF score (log-rank test, P = 0.005). The HF-related event rate was higher in proportion to the H2FPEF score (log-rank test, P &amp;lt; 0.001). Multivariate Cox hazard analyses identified the H2FPEF score (per 1 point) as an independent predictor of cardiovascular and HF-related events (hazard ratio [HR], 1.179; 95% confidence interval [CI], 1.066\u20131.305; P = 0.001 and HR, 1.288; 95% CI, 1.134\u20131.463; P = 0.001, respectively). Receiver operating characteristic analysis showed that the H2FPEF significantly predicted cardiovascular events (area under the curve [AUC], 0.626; 95% CI, 0.557\u20130.693; P &amp;lt; 0.001) and HF-related events (AUC, 0.680; 95% CI, 0.600\u20130.759; P &amp;lt; 0.001). The cutoff H2FPEF score was 5.5 for the identification of cardiovascular and HF-related events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The H2FPEF score might be a potentially useful marker for the prediction of cardiovascular and HF-related events in HFpEF patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trails Registration<\/jats:title>\n                  <jats:p>Trail Number UMIN000029600.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz108","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:10:03Z","timestamp":1562152203000},"page":"1082-1090","source":"Crossref","is-referenced-by-count":74,"title":["H2FPEF Score as a Prognostic Value in HFpEF Patients"],"prefix":"10.1093","volume":"32","author":[{"given":"Daisuke","family":"Sueta","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Oike","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Takae","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Usuku","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Takashio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University , Kumamoto, 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